Year 2023 / Volume 115 / Number 2
Editorial
Liquid biopsy-based microRNA models as potential biomarkers of bowel conditions

59-63

DOI: 10.17235/reed.2022.9027/2022

Óscar Rapado-González, Rafael López-López, María Mercedes Suárez-Cunqueiro,

Abstract
MicroRNAs detected in liquid biopsies have demonstrated to have potential as biomarkers of benign and malignant bowel conditions. Numerous studies have reported on the combination of different microRNAs to improve the diagnostic capabilities in the detection of bowel conditions. This editorial will be reviewing the best scientific evidence available to this date on studies showing microRNA models with sensitivity and specificity values. Also, the current challenges on how to implement microRNAs in the routine clinical practice are exposed.
Share Button
New comment
Comments
No comments for this article
References
1. Giráldez MD, Lozano JJ, Ramírez G, et al. Circulating microRNAs as biomarkers of colorectal cancer: Results From a genome-wide profiling and validation study. Clin Gastroenterol Hepatol 2013,11:681–8.e3.
2. Kanaan Z, Roberts H, Eichenberger MR, et al. A plasma microRNA panel for detection of colorectal adenomas: A step toward more precise screening for colorectal cancer. Ann Surg 2013,258:400–8.
3. Wang S, Xiang J, Li Z, et al. A plasma microRNA panel for early detection of colorectal cancer. Int J Cancer 2015,136:152–61.
4. Fang Z, Tang J, Bai Y, et al. Plasma levels of microRNA-24, microRNA-320a, and microRNA-423-5p are potential biomarkers for colorectal carcinoma. J Exp Clin Cancer Res 2015,34:86.
5. Carter J V., Roberts HL, Pan J, et al. A highly predictive model for diagnosis of colorectal neoplasms using plasma microRNA. Ann Surg 2016,264:575–84.
6. Liu X, Pan B, Sun L, et al. Circulating exosomal miR-27a and miR-130a act as novel diagnostic and prognostic biomarkers of colorectal cancer. Cancer Epidemiol Biomarkers Prev 2018,27:746–54.
7. Zhang H, Zhu M, Shan X, et al. A panel of seven-miRNA signature in plasma as potential biomarker for colorectal cancer diagnosis. Gene 2018,687:246–54.
8. Tan Y, Lin JJ, Yang X, et al. A panel of three plasma microRNAs for colorectal cancer diagnosis. Cancer Epidemiol 2019,60:67–76.
9. Herreros-Villanueva M, Duran-Sanchon S, Martín AC, et al. Plasma microRNA signature validation for early detection of colorectal cancer. Clin Transl Gastroenterol 2019,10:e00003.
10. Silva CMS, Barros-Filho MC, Wong DVT, et al. Circulating let-7e-5p, miR-106a-5p, miR-28-3p, and miR-542-5p as a promising microrna signature for the detection of colorectal cancer. Cancers (Basel) 2021,13:1493.
11. Nassar FJ, Msheik ZS, Itani MM, et al. Circulating miRNA as biomarkers for colorectal cancer diagnosis and liver metastasis. Diagnostics (Basel) 2021,11:341.
12. Vychytilova-Faltejskova P, Radova L, Sachlova M, et al. Serum-based microRNA signatures in early diagnosis and prognosis prediction of colon cancer. Carcinogenesis 2016,37:941–50.
13. Zheng G, Du L, Yang X, et al. Serum microRNA panel as biomarkers for early diagnosis of colorectal adenocarcinoma. Br J Cancer 2014,111:1985–92.
14. Liu HN, Liu TT, Wu H, et al. Serum microRNA signatures and metabolomics have high diagnostic value in colorectal cancer using two novel methods. Cancer Sci 2018,109:1185–94.
15. Guo S, Zhang J, Wang B, et al. A 5-serum miRNA panel for the early detection of colorectal cancer. Onco Targets Ther 2018,11:2603–14.
16. Marcuello M, Duran-Sanchon S, Moreno L, et al. Analysis of a 6-miRNA signature in serum from colorectal cancer screening participants as non-invasive biomarkers for advanced adenoma and colorectal cancer detection. Cancers (Basel) 2019,11:1542.
17. Peng X, Wang J, Zhang C, et al. A three-miRNA panel in serum as a noninvasive biomarker for colorectal cancer detection. Int J Biol Markers 2020,35:74–82.
18. Huang G, Wei B, Chen Z, et al. Identification of a four-microRNA panel in serum as promising biomarker for colorectal carcinoma detection. Biomark Med 2020,14:749–60.
19. Shi Y, Zhuang Y, Zhang J, et al. Four circulating exosomal miRNAs as novel potential biomarkers for the early diagnosis of human colorectal cancer. Tissue Cell 2021,70:101499.
20. Han L, Shi WJ, Xie YB, Zhang ZG. Diagnostic value of four serum exosome microRNAs panel for the detection of colorectal cancer. World J Gastrointest Oncol 2021,13:970–9.
21. Rapado-González, Majem, Álvarez-Castro, et al. A novel saliva-based miRNA signature for colorectal cancer diagnosis. J Clin Med 2019,8:2029.
22. Bader El Din NG, Ibrahim MK, El‐Shenawy R, et al. MicroRNAs expression profiling in Egyptian colorectal cancer patients. IUBMB Life 2020,72:275–84.
Citation tools
Rapado-González Ó, López-López R, Suárez-Cunqueiro M. Liquid biopsy-based microRNA models as potential biomarkers of bowel conditions. 9027/2022


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 1226 visits.
This article has been downloaded 88 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 21/06/2022

Accepted: 23/06/2022

Online First: 01/12/2022

Published: 07/02/2023

Article Online First time: 163 days

Article editing time: 231 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology