Year 2019 / Volume 111 / Number 2
Original
Independent factors associated with the impact of gastroesophageal reflux disease on health-related quality of life

94-100

DOI: 10.17235/reed.2018.5752/2018

Ana Zatarain Valles, Blanca Serrano Falcón, Ángel Álvarez Sánchez, Enrique Rey Díaz-Rubio,

Abstract
Background: although a number of factors have been associated with a deterioration in quality of life in gastroesophageal reflux disease, it is not known which has an independent influence. Objective: to evaluate factors independently associated with the impact of gastroesophageal reflux disease on health-related quality of life. Methods: a post-hoc analysis of a prospective cohort of patients diagnosed with gastroesophageal reflux disease was performed. The patients completed validated questionnaires to evaluate health-related quality of life (SF 36), gastroesophageal reflux disease (GERQ) and psychological factors (STAI and SCL 90R). Results: the study included 98 patients. The univariate analysis showed that a deterioration in the physical component of the SF36 was significantly associated with female gender, educational level, age, weight loss, severity of typical symptoms, supraesophageal symptoms and monthly income. The mental component was significantly associated with alcohol consumption, epigastric pain and lower scores on the STAI and SCL90 questionnaires. The multivariate analysis showed an independent association between the physical component of the SF36 and educational level (β = 0.29; p < 0.01), severity of symptoms (β = -0.38; p < 0.001), body mass index (β = -0.30; p < 0.005), state anxiety (β = 0.28; p < 0.01), female gender (β = -0.23; p < 0.05) and dyspepsia (β = -0.21; p < 0.05). Associated variables within the mental component included state anxiety (β = -0.39; p < 0.01) and depression (β = -0.32; p < 0.05). Conclusions: the principal factors independently associated with a deterioration in health-related quality of life in patients with gastroesophageal reflux disease included the severity of typical symptoms and the presence of dyspepsia. There is also an additional impact of body mass index and the psychological component.
Share Button
New comment
Comments
No comments for this article
References
1. Dent J. Epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut. 2005 May 1;54(5):710–7.
2. Diaz-Rubio M, Moreno-Elola-Olaso C, Rey E, Locke GR, Rodriguez-Artalejo F. Symptoms of gastro-oesophageal reflux: prevalence, severity, duration and associated factors in a Spanish population. Aliment Pharmacol Ther. 2004 Jan;19(1):95–105.
3. Rey E, Alvarez-Sánchez A, Rodríguez-Artalejo F, Moreno Elola-Olaso C, Almansa C, Díaz-Rubio M. Onset and disappearance rates of gastroesophageal reflux symptoms in the Spanish population, and their impact on quality of life. Rev Esp Enferm Dig. 2009;101(7):477.
4. Barcelo M, Sanchez AA, Sanchez RG, Diaz-Rubio M, Rey E. Weight gain and somatization are associated with the onset of gastroesophageal reflux diseases: results of two 5-year follow-up studies. J Clin Gastroenterol. 2016;50(3):202–207.
5. Dean BB, Aguilar D, Johnson LF, Mcguigan JE, Orr WC, Fass R, et al. Night-time and daytime atypical manifestations of gastro-oesophageal reflux disease: frequency, severity and impact on health-related quality of life: ATYPICAL MANIFESTATIONS OF GERD. Aliment Pharmacol Ther. 2007 Nov 13;27(4):327–37.
6. Rey E, Elola-Olaso CM, Rodríguez-Artalejo F, Locke GR, Díaz-Rubio M. Prevalence of atypical symptoms and their association with typical symptoms of gastroesophageal reflux in Spain. Eur J Gastroenterol Hepatol. 2006;18(9):969–975.
7. Rasmussen S, Jensen TH, Henriksen SL, Haastrup PF, Larsen PV, Søndergaard J, et al. Overlap of symptoms of gastroesophageal reflux disease, dyspepsia and irritable bowel syndrome in the general population. Scand J Gastroenterol. 2015 Feb;50(2):162–9.
8. Rey E, García-Alonso M, Moreno-Ortega M, Almansa C, Alvarez-Sanchez A, Díaz-Rubio M. Influence of Psychological Distress on Characteristics of Symptoms in Patients with GERD: The Role of IBS Comorbidity. Dig Dis Sci. 2009 Feb;54(2):321–7.
9. Hansen JM, Wildner-Christensen M, Schaffalitzky de Muckadell OB. Gastroesophageal Reflux Symptoms in a Danish Population: A Prospective Follow-Up Analysis of Symptoms, Quality of Life, and Health-Care Use. Am J Gastroenterol. 2009 Jul 21;104(10):2394–403.
10. Gisbert JP, Cooper A, Karagiannis D, Hatlebakk J, Agréus L, Jablonowski H, et al. Impact of gastroesophageal reflux disease on patients’ daily lives: a European observational study in the primary care setting. Health Qual Life Outcomes. 2009;7(1):60.
11. Ronkainen J, Aro P, Storskrubb T, Lind T, Bolling-Sternevald E, Junghard O, et al. Gastro-oesophageal reflux symptoms and health-related quality of life in the adult general population - the Kalixanda study. Aliment Pharmacol Ther. 2006 Jun;23(12):1725–33.
12. Ponce J, Beltrán B, Ponce M, Zapardiel J, Ortiz V, Vegazo O, et al. Impact of gastroesophageal reflux disease on the quality of life of Spanish patients: the relevance of the biometric factors and the severity of symptoms: Eur J Gastroenterol Hepatol. 2009 Jun;21(6):620–9.
13. Stanislas Bruley Des Varannes RC Lizzie Marek, Benoist Humeau, Marc Lecasble. Gastroesophageal reflux disease in primary care. Gastroentérologie Clin Biol. 2006;1224(3):351–501.
14. Díaz de Liaño á., Yárnoz C, Artieda C, Flores L, Garde C, Romeo I, et al. Gastroesophageal reflux: prevalence of psychopathological disorders and quality of life implications. Dis Esophagus. 2006 Oct;19(5):373–6.
15. De Vries DR, Van Herwaarden MA, Baron A, Smout AJPM, Samsom M. Concomitant functional dyspepsia and irritable bowel syndrome decrease health-related quality of life in gastroesophageal reflux disease. Scand J Gastroenterol. 2007 Jan;42(8):951–6.
16. Testa MA, Simonson DC. Assessment of quality-of-life outcomes. N Engl J Med. 1996;334(13):835–840.
17. Moreno Elola-Olaso C, Rey E, Rodriguez-Artalejo, Locke GR, Diaz Rubio M. Adaptation and validation of a gastroesophageal reflux questionnaire for use on a Spanish population. Rev Espanola Enfermedades Dig Organo Of Soc Espanola Patol Dig. 2002;94(12):745–58.
18. Alonso J, Prieto L, Antó JM. La versión española del SF-36 Health Survey (Cuestionario de Salud SF-36): un instrumento para la medida de los resultados clínicos. Med Clin Barc. 1995;104(20):771–776.
19. Spielberger C, Gorsuch R, Lushene R. STAI Cuestionario de Ansiedad Estado Rasgo.(Adaptación española: Nicolás Seisdedos Cubero). 1994;
20. González de Rivera JL, De las Cuevas C, Rodríguez M, Rodríguez F. Cuestionario de 90 síntomas SCL-90-R de Derogatis, L. Adapt Esp Madr TEA Ediciones. 2002;
21. Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional Bowel Disorders. Gastroenterology. 2006 Apr;130(5):1480–91.
22. Tack J, Becher A, Mulligan C, Johnson DA. Systematic review: the burden of disruptive gastro-oesophageal reflux disease on health-related quality of life. Aliment Pharmacol Ther. 2012 Jun;35(11):1257–66.
23. Wiklund I. Review of the Quality of Life and Burden of Illness in Gastroesophageal Reflux Disease. Dig Dis. 2004 Sep 23;22(2):108–14.
24. Wahlqvist P. Symptoms of gastroesophageal reflux disease, perceived productivity, and health-related quality of life. Am J Gastroenterol. 2001;96(8):S57–S61.
25. Irvine EJ. Quality of life assessment in gastro-oesophageal reflux disease. Gut. 2004 May 1;53(suppl_4):iv35-iv39.
26. Manabe N, Haruma K, Hata J, Kamada T, Kusunoki H. Differences in recognition of heartburn symptoms between Japanese patients with gastroesophageal reflux, physicians, nurses, and healthy lay subjects. Scand J Gastroenterol. 2008 Jan;43(4):398–402.
27. Mearin F, Ponce J, Ponce M, Balboa A, Gónzalez MA, Zapardiel J. Frequency and clinical implications of supraesophageal and dyspeptic symptoms in gastroesophageal reflux disease: Eur J Gastroenterol Hepatol. 2012 Jun;24(6):665–74.
28. Friedenberg FK, Xanthopoulos M, Foster GD, Richter JE. The Association Between Gastroesophageal Reflux Disease and Obesity. Am J Gastroenterol. 2008 Aug;103(8):2111–22.
29. Rey E, Moreno-Elola-Olaso C, Artalejo FR, Locke GR, Diaz-Rubio M. Association between Weight Gain and Symptoms of Gastroesophageal Reflux in the General Population. Am J Gastroenterol. 2006 Feb;101(2):229–33.
30. Lee S-W. Impact of body mass index and gender on quality of life in patients with gastroesophageal reflux disease. World J Gastroenterol. 2012;18(36):5090.
31. Lee SY, Lee KJ, Kim SJ, Cho SW. Prevalence and Risk Factors for Overlaps between Gastroesophageal Reflux Disease, Dyspepsia, and Irritable Bowel Syndrome: A Population-Based Study. Digestion. 2009;79(3):196–201.
32. Jung H-K, Halder S, Mcnally M, Locke Iii GR, Schleck CD, Zinsmeister AR, et al. Overlap of gastro-oesophageal reflux disease and irritable bowel syndrome: prevalence and risk factors in the general population: OVERLAP OF GERD AND IBS. Aliment Pharmacol Ther. 2007 May 5;26(3):453–61.
33. Bortoli N de. Overlap of functional heartburn and gastroesophageal reflux disease with irritable bowel syndrome. World J Gastroenterol. 2013;19(35):5787.
34. Rey E, García-Arredondo M. Enfermedad por reflujo gastroesofágico y síndrome de intestino irritable: ¿por qué se asocian? Rev Esp Enfermedades Dig. 2010;102(4):225–228.
35. Kaji M, Fujiwara Y, Shiba M, Kohata Y, Yamagami H, Tanigawa T, et al. Prevalence of overlaps between GERD, FD and IBS and impact on health-related quality of life: Overlap of FGIDs and HR-QOL. J Gastroenterol Hepatol. 2010 Jun;25(6):1151–6.
36. Hartono JL, Mahadeva S, Goh K-L. Anxiety and depression in various functional gastrointestinal disorders: Do differences exist?: Anxiety and depression in FGIDs. J Dig Dis. 2012 May;13(5):252–7.
37. Yang X-J. Anxiety and depression in patients with gastroesophageal reflux disease and their effect on quality of life. World J Gastroenterol. 2015;21(14):4302.
38. Avidan B, Sonnenberg A, Giblovich H, Sontag SJ. Reflux symptoms are associated with psychiatric disease. Aliment Pharmacol Ther. 2001;15(12):1907–1912.
39. Lippmann QK, Crockett SD, Dellon ES, Shaheen NJ. Quality of Life in GERD and Barrett’s Esophagus Is Related to Gender and Manifestation of Disease. Am J Gastroenterol. 2009 Nov;104(11):2695–703.
40. Dore MP, Maragkoudakis E, Fraley K, Pedroni A, Tadeu V, Realdi G, et al. Diet, Lifestyle and Gender in Gastro-Esophageal Reflux Disease. Dig Dis Sci. 2008 Aug;53(8):2027–32.
41. Verma AK, Schulte PJ, Bittner V, Keteyian SJ, Fleg JL, Piña IL, et al. Socioeconomic and partner status in chronic heart failure: Relationship to exercise capacity, quality of life, and clinical outcomes. Am Heart J. 2017 Jan;183:54–61.
Related articles

Digestive Diseases Image

A rare endoscopic pattern in a patient with gastroesophageal reflux disease

DOI: 10.17235/reed.2022.9124/2022

Letter

How is the duodenal mucosa in functional dyspepsia?

DOI: 10.17235/reed.2020.7673/2020

Letter

Dyspepsia, functional dyspepsia and Rome IV criteria

DOI: 10.17235/reed.2018.5599/2018

Letter to the Editor

A question about dyspeptic patients analyzed using psychometric scores

DOI: 10.17235/reed.2017.5401/2017

Citation tools
Zatarain Valles A, Serrano Falcón B, Álvarez Sánchez Á, Rey Díaz-Rubio E. Independent factors associated with the impact of gastroesophageal reflux disease on health-related quality of life. 5752/2018


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 1467 visits.
This article has been downloaded 326 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 29/05/2018

Accepted: 07/08/2018

Online First: 22/10/2018

Published: 01/02/2019

Article revision time: 65 days

Article Online First time: 146 days

Article editing time: 248 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology