Year 2022 / Volume 114 / Number 12
Letter
Dual biologic therapy for severe ulcerative colitis, concomitant extraintestinal manifestations and an orbital osteoma: a successful treatment

757-758

DOI: 10.17235/reed.2022.8964/2022

Cong Dai Peter, Yu-hong Huang, Wen-ning Tian,

Abstract
It is difficult to manage UC patients with tumor and extraintestinal manifestations (EIMs). We present this case of acute severe UC patient with peripheral arthritis and orbital tumor could be successfully managed by the concomitant use of two biologics (Dual targeted therapy, DTT) including vedolizumab (VDZ) and ustekinumab (UST). VDZ is approved for the treatment of patients with moderate-to-severe UC, but might have limited efficacy in treating EIMs due to its gut specific mechanism. UST shows clinical efficacy in the treatment of EIMs and is used for UC treatment.
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Peter C, Huang Y, Tian W. Dual biologic therapy for severe ulcerative colitis, concomitant extraintestinal manifestations and an orbital osteoma: a successful treatment. 8964/2022


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Publication history

Received: 27/05/2022

Accepted: 27/06/2022

Online First: 30/06/2022

Published: 12/12/2022

Article revision time: 27 days

Article Online First time: 34 days

Article editing time: 199 days


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