Year 2008 / Volume 100 / Number 5
Original
An analysis of the causes, characteristics, and consequences of reexposure to a drug or compound responsible for a hepatotoxicity event

pp. 278-284

Fernández-Castañer, A. / García-Cortés, M. / Lucena, M. I. / Borraz, Y. / Peláez, G. / Costa, J. / Anzola, S. / Salmerón, J. / Ávila, S. / Durán, J. A. / Malcón de Dios, A. / Romero-Gómez, M. / Madrazo, A. / Muñoz-Yagüe, T. / A

Abstract
Introduction: reexposure to a causal agent represents a potentially serious event in hepatotoxicity.

Objectives: to assess the characteristics and outcome of cases with positive reexposure.

Material and methods: a retrospective study of cases with evidence of positive reexposure included in Registro Español de Hepatopatías Asociadas a Medicamentos, and an analysis of their relation to demographic and clinical variables, causality, course, and consequences.

Results: of a total of 520 cases 31 (6%) met reexposure criteria. Fatal outcomes, needs for admission, and mean recovery time were all higher for hepatocellular-type toxic injury. The most commonly identified drug class was antibiotics. On most occasions (73%) reexposure to the causal compound escaped notice because of: absence of index case diagnosis, lack of information to patients and their physicians, and (12%) development of cross reactions between structurally similar drugs.

Conclusions: accidental reexposure to a drug or a structurally-related compound after an initial hepatotoxicity event is common and may have serious consequences, particularly in hepatocellular-type toxicity. Careful history taking and reflecting diagnostic suspicion in the initial episode’s record may reduce the incidence of this iatrogenic event.
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Comments

13/03/2023 19:04:20
Rectifico, lo he encontrado en Español, el estudio es extraordinario, muy práctico

Muchas gracias

Mario Apón


13/03/2023 18:20:40
Hablan de reexposición, pero no encuentro el estudio en Español


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Fernández-Castañer, A. / García-Cortés, M. / Lucena, M. I. / Borraz, Y. / Peláez, G. / Costa, J. / Anzola, S. / Salmerón, J. / Ávila, S. / Durán, J. A. / Malcón de Dios, A. / Romero-Gómez, M. / Madrazo, A. / Muñoz-Yagüe, T. / A. An analysis of the causes, characteristics, and consequences of reexposure to a drug or compound responsible for a hepatotoxicity event. 278-284


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