Year 2015 / Volume 107 / Number 12
Letter to the Editor
Recurrent drug-induced liver injury (DILI) with ciprofloxacin and amoxicillin/clavulanic

767-768

DOI: 10.17235/reed.2015.3810/2015

Luís Moreno, Jordi Sánchez Delgado, Mercedes Vergara, Meritxell Casas, Mireia Miquel, Blai Dalmau,

Abstract
Ciprofloxacin and amoxicillin/clavulanic are two widely used antibiotics due to their high efficacy and few side effects. While the percentage of hepatotoxicity of these antibiotics is low, their frequent use has led to a progressive increase in the number of cases. Both antibiotics have been associated with a wide variety of hepatotoxic reactions, from a slight rise of transaminases to fulminant hepatitis. Once hepatotoxicity secondary to a drug appears, the first step is to discontinue the drug. Physicians may opt to administer an alternative treatment with a different chemical structure. It should be borne in mind, however, that different chemical structures may also cause recurrent drug-induced liver injuries (DILI). We present the case of a patient who consecutively developed DILI due to ciprofloxacin and amoxicillin/clavulanic.
Share Button
New comment
Comments
No comments for this article
References
1. Lucena MI, Kaplowitz N, Hallal H, et al. Recurrent drug-induced liver injury (DILI) with different drugs in the Spanish Registry: the dilemma of the relationship to autoimmune hepatitis. J.Hepatol. 2011; 55: 820-7.
2. Alcalde M, Donoso MS, Carcfa-Diaz M, et al. Liver disfunction due to ciprofloxacin. Acta Gastroenterol.Belg. 1995; 58: 475-6.
3. Bataille L, Rahier J, Geubel A. Delayed and prolonged cholestatic hepatitis with ductopenia after long-term ciprofloxacin therapy for Crohn's disease. J Hepatol. 2002; 37: 696-9.
4. Bhagirath KM. A case report of highly suspected ciprofloxacin-induced hepatotoxicity. Turk J Gastroenterol. 2008; 19: 204-6.
5. Contreras MA, Luna R, Mulero J, et al. Severe ciprofloxacin-induced acute hepatitis. Eur J Clin Microbiol Infect Dis. 2001; 20: 434-5.
6. Dominguez Jimenez JL, Marin MM, Bernal BE, et al. [Acute cholestatic hepatitis induced by amoxicillin-clavulanic acid]. Gastroenterol Hepatol. 2008; 31: 46.
7. Garcia Rodriguez LA, Stricker BH, Zimmerman HJ. Risk of acute liver injury associated with the combination of amoxicillin and clavulanic acid. Arch Intern Med. 1996; 156: 1327-32.
8. Hebbard GS, Smith KG, Gibson PR, et al. Augmentin-induced jaundice with a fatal outcome. Med J Aust. 1992; 156: 285-6.
Related articles

Editorial

Hemophilia and hepatology, back to the future

DOI: 10.17235/reed.2024.10105/2023

Letter

Cefditoren-induced hepatitis

DOI: 10.17235/reed.2022.8801/2022

Letter

Curcumin and curcumoids: hepatoprotection or hepatotoxicity?

DOI: 10.17235/reed.2022.8588/2022

Letter

Severe hepatotoxicity secondary to nintedanib

DOI: 10.17235/reed.2020.7585/2020

Letter

Acute hepatitis due to olmesartan: an uncommon entity

DOI: 10.17235/reed.2020.7236/2020

Case Report

Apixaban-induced liver injury

DOI: 10.17235/reed.2018.5877/2018

Letter to the Editor

Canalicular cholestasis induced by anabolic steroids

DOI: 10.17235/reed.2017.4781/2016

Citation tools
Moreno L, Sánchez Delgado J, Vergara M, Casas M, Miquel M, Dalmau B, et all. Recurrent drug-induced liver injury (DILI) with ciprofloxacin and amoxicillin/clavulanic . 3810/2015


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 284 visits.
This article has been downloaded 232 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 16/04/2015

Accepted: 18/06/2015

Online First: 06/11/2015

Published: 03/12/2015

Article revision time: 61 days

Article Online First time: 204 days

Article editing time: 231 days


Share
This article has been rated by 4 readers.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology