Year 2026 / Volume 118 / Number 2
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Extensive colitis associated with ixekizumab

103-104

DOI: 10.17235/reed.2024.10428/2024

María Luisa López García, María Paz Arreba González, Leire Irusta Olano, Carmen Muñoz Villafranca,

Abstract
We present the clinical case of a 56-year-old former smoker female, with a family history of maternal ulcerative colitis and personal history of ankylosing spondylitis treated with Ixekizumab for 3 months, who was admitted for fever, left iliac fossa pain and diarrhea without pathological products of 2 weeks of evolution. Abdominopelvic computed tomography scan identified pancolitis. Complete colonoscopy revealed continuous involvement of the proximal colon (right and transverse colon presented deep ulcerations and mucosal friability) with preservation of the terminal ileum. After many complementary tests and according to the clinical context, the diagnosis of extensive colitis associated with IL-17 inhibitor was established.
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References
Deng Z, Wang S, Wu C, Wang C, IL-17 inhibitor-associated inflamatory bowel disease: A study based on literatura and database analysis. Pharmacol 2023, 1124628
Grümme L, Dombret S, Knösel T, Skapenko A, Schulze‐Koops H. Colitis induced by IL-17A-inhibitors. Clinical Journal of Gastroenterology. 2024, 17:263–270.
Riveiro-Barciela M, Carballal S, Díaz-González Á, Mañosa M, Gallgo-Plazas J, Cubiella J, Jiménez-Fonseca P, Varela M, Menchén L, Sangro B, Fernández-Montes A, Mesonero F, Rodríguez-Gandía MÁ, Rivera F, Londoño MC. Management of liver and gastrointestinal toxicity induced by immune checkpoint inhibitors: Position statement of the AEEH-AEG-SEPD-SEOM-GETECCU. Rev Esp Enferm Dig. 2024 Feb;116(2):83-113
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López García M, Arreba González M, Irusta Olano L, Muñoz Villafranca C. Extensive colitis associated with ixekizumab. 10428/2024


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Publication history

Received: 24/03/2024

Accepted: 26/03/2024

Online First: 18/04/2024

Published: 09/02/2026

Article Online First time: 25 days

Article editing time: 687 days


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