Año 2024 / Volumen 116 / Número 12
Editorial
Early liver transplantation in severe alcohol-associated hepatitis

661-663

DOI: 10.17235/reed.2024.10881/2024

Jordi Colmenero, Elisa Pose, Hugo López-Pelayo,

Resumen
Early liver transplantation for severe alcohol-associated hepatitis represents a transformative therapeutic approach that can significantly improve survival and achieves standard survival after LT compared to other indications. Early evaluation and an adequate selection of candidates, including organic and psychosocial criteria, are essential. Multidisciplinary management, including the addiction team for the treatment of alcohol use disorder, decreases the risk of alcohol relapse after liver transplantation and is associated with improved outcomes.
Nuevo comentario
Comentarios
No hay comentarios para este artículo.
Bibliografía
1. Bataller, R., Arab, J. P. & Shah, V. H. Alcohol-Associated Hepatitis. N. Engl. J. Med. 387, 2436–2448 (2022). doi: 10.1056/NEJMra2207599
2. Singal, A. K., Bataller, R., Ahn, J., Kamath, P. S. & Shah, V. H. ACG Clinical Guideline: Alcoholic Liver Disease. Am. J. Gastroenterol. 113, 175–194 (2018). DOI: 10.1038/ajg.2017.469
3. Lee, B. P. et al. Designing clinical trials to address alcohol use and alcohol-associated liver disease: an expert panel Consensus Statement. Nat. Rev. Gastroenterol. Hepatol. 21, 626–645 (2024). DOI: 10.1038/s41575-024-00936-x
4. Musto, J. A. & Lucey, M. R. Prognostic models in alcohol-related liver disease and alcohol-related hepatitis. Best Pract. Res. Clin. Gastroenterol. 67, (2023).
5. Garcia-Saenz-De-Sicilia, M. et al. A Day-4 Lille Model Predicts Response to Corticosteroids and Mortality in Severe Alcoholic Hepatitis. Am. J. Gastroenterol. 112, 306–315 (2017). DOI: 10.1038/ajg.2016.539
6. Louvet, A. et al. The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids. Hepatology 45, 1348–1354 (2007).
7. Mathurin, P. et al. Early liver transplantation for severe alcoholic hepatitis. N. Engl. J. Med. 365, 1790–1800 (2011). DOI: 10.1056/NEJMoa1105703
8. Lee, B. P. et al. Outcomes of Early Liver Transplantation for Patients With Severe Alcoholic Hepatitis. Gastroenterology 155, 422-430.e1 (2018).
9. Louvet, A. et al. Early liver transplantation for severe alcohol-related hepatitis not responding to medical treatment: a prospective controlled study. lancet. Gastroenterol. Hepatol. 7, 416–425 (2022). DOI: 10.1016/S2468-1253(21)00430-1
10. Im, G. Y. et al. Early Liver Transplantation for Severe Alcoholic Hepatitis in the United States - A Single-Center Experience. Am. J. Transplant. 16, 841–849 (2016). DOI: 10.1111/ajt.13586
11. Masson, S., Taylor, R. & Thorburn, D. Long-term Outcomes From the UK Pilot of Early Liver Transplantation for Severe Alcohol-related Hepatitis. Transplantation 108, e198–e199 (2024).
12. Burra, P. et al. Liver transplantation for alcoholic liver disease in Europe: A study from the ELTR (European liver transplant registry). Am. J. Transplant. 10, 138–148 (2010). DOI: 10.1111/j.1600-6143.2009.02869.x
13. Weeks, S. R. et al. Liver Transplantation for Severe Alcoholic Hepatitis, Updated Lessons from the World’s Largest Series. J. Am. Coll. Surg. 226, 549–557 (2018). DOI: 10.1016/j.jamcollsurg.2017.12.044
14. GBD 2016 Risk Factors Collaborators, E. et al. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet (London, England) 390, 1345–1422 (2017).
15. Lee, B. P. et al. Model to Calculate Harms and Benefits of Early vs Delayed Liver Transplantation for Patients With Alcohol-Associated Hepatitis. Gastroenterology 157, 472-480.e5 (2019).
16. Lombardo-Quezada, J. et al. Prediction of Alcohol Relapse Among Liver Transplant Candidates With Less Than 6 Months of Abstinence Using the High-Risk Alcoholism Relapse Score. Liver Transpl. 25, 1142–1154 (2019). DOI: 10.1002/lt.25460
17. Pfitzmann, R. et al. Long-term survival and predictors of relapse after orthotopic liver transplantation for alcoholic liver disease. Liver Transpl. 13, 197–205 (2007). DOI: 10.1002/lt.20934
18. Herrick-Reynolds, K. M. et al. Evaluation of Early vs Standard Liver Transplant for Alcohol-Associated Liver Disease. JAMA Surg. 156, 1026–1034 (2021). DOI: 10.1001/jamasurg.2021.3748
19. Lee, B. P. et al. Patterns of Alcohol Use After Early Liver Transplantation for Alcoholic Hepatitis. Clin. Gastroenterol. Hepatol. 20, 409-418.e5 (2022).
20. Kwon, H. M. et al. Benefits of liver transplant in critically ill patients with acute-on-chronic liver failure: Implementation of an urgent living-donor program. Am. J. Transplant (2024) doi:10.1016/J.AJT.2024.08.008.
21. Asrani, S. K. et al. Meeting Report: The Dallas Consensus Conference on Liver Transplantation for Alcohol Associated Hepatitis. Liver Transplant. 26, 127–140 (2020). DOI: 10.1002/lt.25681
22. Satapathy, S. K. et al. Predicting harmful alcohol relapse after liver transplant: The HALT score. Clin. Transplant. 34, (2020).
23. Daniel, J. et al. Integrating an addiction team into the management of patients transplanted for alcohol-associated liver disease reduces the risk of severe relapse. JHEP reports Innov. Hepatol. 5, (2023).
24. Rodríguez-Perálvarez, M. et al. Expanding Indications of Liver Transplantation in Spain: Consensus Statement and Recommendations by the Spanish Society of Liver Transplantation. Transplantation 105, 602–607 (2021).
25. DiMartini, A. et al. Use of a high-risk alcohol relapse scale in evaluating liver transplant candidates. Alcohol. Clin. Exp. Res. 24, 1198–1201 (2000). doi.org/10.1111/j.1530-0277.2000.tb02083.x
Artículos relacionados

Carta

Síndrome de Abernethy como causa de trasplante hepático

DOI: 10.17235/reed.2024.10561/2024

Imagen en Patología Digestiva

Síndrome de encefalopatía posterior reversible (PRES) en el postrasplante hepático

DOI: 10.17235/reed.2022.8694/2022

Carta

Neurotoxicidad por ertapenem

DOI: 10.17235/reed.2021.8469/2021

Revisión

La fragilidad física en el contexto del trasplante hepático

DOI: 10.17235/reed.2020.7448/2020

Carta

Manejo de los aneurismas de la arteria hepática

DOI: 10.17235/reed.2020.7219/2020

Imagen en Patología Digestiva

Hemangioendotelioma epitelioide como causa infrecuente de tumor hepático

DOI: 10.17235/reed.2020.7127/2020

Carta al Editor

Post-transplant lymphoproliferative disease after liver transplantation

DOI: 10.17235/reed.2017.5387/2017

Original

Síndrome linfoproliferativo en el trasplante hepático

DOI: 10.17235/reed.2017.4228/2016

Instrucciones para citar
Colmenero J, Pose E, López-Pelayo H. Early liver transplantation in severe alcohol-associated hepatitis. 10881/2024


Descargar en un gestor de citas

Descargue la cita de este artículo haciendo clic en uno de los siguientes gestores de citas:

Métrica
Este artículo ha sido visitado 1802 veces.
Este artículo ha sido descargado 211 veces.

Estadísticas de Dimensions


Estadísticas de Plum Analytics

Ficha Técnica

Recibido: 22/10/2024

Aceptado: 24/10/2024

Prepublicado: 12/11/2024

Publicado: 13/12/2024

Tiempo de prepublicación: 21 días

Tiempo de edición del artículo: 52 días


Compartir
Este artículo aun no tiene valoraciones.
Valoración del lector:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
La REED es el órgano oficial de la Sociedad Española de Patología Digestiva, la SociedadEspañola de Endoscopia Digestiva y la Asociación Española de Ecografía Digestiva
Política de cookies Política de Privacidad Aviso Legal © Copyright 2025 y Creative Commons. Revista Española de Enfermedades Digestivas