References
                                            
                                                    
                                                        1	Mowat C, Cole A, Windsor A, et al. Guidelines for the management of inflammatory bowel disease in adults. Gut. 2011;60(5):571-607.
                                                     
                                                    
                                                
                                                    
                                                        2	Scheinfeld N. A comprehensive review and evaluation of the side effects of the tumor necrosis factor alpha blockers etanercept, infliximab and adalimumab. J Dermatolog Treat. 2004;15(5):280-294.
                                                     
                                                    
                                                
                                                    
                                                        3	Wiens A, Venson R, Correr CJ, Otuki MF, Pontarolo R. Meta-analysis of the efficacy and safety of adalimumab, etanercept, and infliximab for the treatment of rheumatoid arthritis. Pharmacotherapy. 2010;30(4):339-353.
                                                     
                                                    
                                                
                                                    
                                                        4	Clarke K, Regueiro M. Stopping immunomodulators and biologics in inflammatory bowel disease patients in remission. Inflamm Bowel Dis. 2012;18(1):174-179.
                                                     
                                                    
                                                
                                                    
                                                        5	Doherty G, Katsanos KH, Burisch J, et al. European Crohn's and Colitis Organisation Topical Review on Treatment Withdrawal ['Exit Strategies'] in Inflammatory Bowel Disease. J Crohns Colitis. 2018;12(1):17-31.
                                                     
                                                    
                                                
                                                    
                                                        6	Louis E, Belaiche J, Reenaers C. Anti-TNF and Crohn's disease: when should we stop? Curr Drug Targets. 2010;11(2):148-151.
                                                     
                                                    
                                                
                                                    
                                                        7	Gisbert JP, Marin AC, Chaparro M. The Risk of Relapse after Anti-TNF Discontinuation in Inflammatory Bowel Disease: Systematic Review and Meta-Analysis. Am J Gastroenterol. 2016;111(5):632-647.
                                                     
                                                    
                                                
                                                    
                                                        8	Pauwels RWM, van der Woude CJ, Nieboer D, et al. Prediction of Relapse After Anti-Tumor Necrosis Factor Cessation in Crohn's Disease: Individual Participant Data Meta-analysis of 1317 Patients From 14 Studies. Clin Gastroenterol Hepatol. 2022;20(8):1671-1686 e16.
                                                     
                                                    
                                                
                                                    
                                                        9	Bortlik M, Duricova D, Machkova N, et al. Discontinuation of anti-tumor necrosis factor therapy in inflammatory bowel disease patients: a prospective observation. Scand J Gastroenterol. 2016;51(2):196-202.
                                                     
                                                    
                                                
                                                    
                                                        10	Bots SJ, Kuin S, Ponsioen CY, et al. Relapse rates and predictors for relapse in a real-life cohort of IBD patients after discontinuation of anti-TNF therapy. Scand J Gastroenterol. 2019;54(3):281-288.
                                                     
                                                    
                                                
                                                    
                                                        11	Casanova MJ, Chaparro M, Garcia-Sanchez V, et al. Evolution After Anti-TNF Discontinuation in Patients With Inflammatory Bowel Disease: A Multicenter Long-Term Follow-Up Study. Am J Gastroenterol. 2017;112(1):120-131.
                                                     
                                                    
                                                
                                                    
                                                        12	Casanova MJ, Chaparro M, Nantes O, et al. Clinical outcome after anti-tumour necrosis factor therapy discontinuation in 1000 patients with inflammatory bowel disease: the EVODIS long-term study. Aliment Pharmacol Ther. 2021;53(12):1277-1288.
                                                     
                                                    
                                                
                                                    
                                                        13	Dai C, Liu WX, Jiang M, Sun MJ. Mucosal healing did not predict sustained clinical remission in patients with IBD after discontinuation of one-year infliximab therapy. PLoS One. 2014;9(10):e110797.
                                                     
                                                    
                                                
                                                    
                                                        14	Fiorino G, Cortes PN, Ellul P, et al. Discontinuation of Infliximab in Patients With Ulcerative Colitis Is Associated With Increased Risk of Relapse: A Multinational Retrospective Cohort Study. Clin Gastroenterol Hepatol. 2016;14(10):1426-1432 e1421.
                                                     
                                                    
                                                
                                                    
                                                        15	Gisbert JP, Marin AC, Chaparro M. Systematic review: factors associated with relapse of inflammatory bowel disease after discontinuation of anti-TNF therapy. Aliment Pharmacol Ther. 2015;42(4):391-405.
                                                     
                                                    
                                                
                                                    
                                                        16	Kobayashi T, Motoya S, Nakamura S, et al. Discontinuation of infliximab in patients with ulcerative colitis in remission (HAYABUSA): a multicentre, open-label, randomised controlled trial. Lancet Gastroenterol Hepatol. 2021;6(6):429-437.
                                                     
                                                    
                                                
                                                    
                                                        17	Lee JM, Kim YJ, Lee KM, et al. Long-term clinical outcome after infliximab discontinuation in patients with inflammatory bowel disease. Scand J Gastroenterol. 2018;53(10-11):1280-1285.
                                                     
                                                    
                                                
                                                    
                                                        18	Mahmoud R, Savelkoul EHJ, Mares W, et al. Complete Endoscopic Healing Is Associated With Lower Relapse Risk After Anti-TNF Withdrawal in Inflammatory Bowel Disease. Clin Gastroenterol Hepatol. 2022.
                                                     
                                                    
                                                
                                                    
                                                        19	Molander P, Farkkila M, Kemppainen H, et al. Long-term outcome of inflammatory bowel disease patients with deep remission after discontinuation of TNFalpha-blocking agents. Scand J Gastroenterol. 2017;52(3):284-290.
                                                     
                                                    
                                                
                                                    
                                                        20	Molander P, Farkkila M, Salminen K, et al. Outcome after discontinuation of TNFalpha-blocking therapy in patients with inflammatory bowel disease in deep remission. Inflamm Bowel Dis. 2014;20(6):1021-1028.
                                                    
                                                    
                                                
                                                    
                                                        21	Song JH, Kang EA, Park SK, et al. Long-term Outcomes after the Discontinuation of Anti-Tumor Necrosis Factor-alpha Therapy in Patients with Inflammatory Bowel Disease under Clinical Remission: A Korean Association for the Study of Intestinal Disease Multicenter Study. Gut Liver. 2021;15(5):752-762.
                                                     
                                                    
                                                
                                                    
                                                        22	Steenholdt C, Molazahi A, Ainsworth MA, Brynskov J, Ostergaard Thomsen O, Seidelin JB. Outcome after discontinuation of infliximab in patients with inflammatory bowel disease in clinical remission: an observational Danish single center study. Scand J Gastroenterol. 2012;47(5):518-527.
                                                     
                                                    
                                                
                                                    
                                                        23	Brooks AJ, Sebastian S, Cross SS, et al. Outcome of elective withdrawal of anti-tumour necrosis factor-alpha therapy in patients with Crohn's disease in established remission. J Crohns Colitis. 2017;11(12):1456-1462.
                                                    
                                                    
                                                
                                                    
                                                        24	Caviglia R, Ribolsi M, Rizzi M, Emerenziani S, Annunziata M, Cicala M. Maintenance of remission with infliximab in inflammatory bowel disease: efficacy and safety long-term follow-up. World J Gastroenterol. 2007;13(39):5238-5244.
                                                     
                                                    
                                                
                                                    
                                                        25	Chauvin A, Le Thuaut A, Belhassan M, et al. Infliximab as a bridge to remission maintained by antimetabolite therapy in Crohn's disease: A retrospective study. Dig Liver Dis. 2014;46(8):695-700.
                                                     
                                                    
                                                
                                                    
                                                        26	Crombe V, Salleron J, Savoye G, et al. Long-term outcome of treatment with infliximab in pediatric-onset Crohn's disease: a population-based study. Inflamm Bowel Dis. 2011;17(10):2144-2152.
                                                     
                                                    
                                                
                                                    
                                                        27	Domenech E, Hinojosa J, Nos P, et al. Clinical evolution of luminal and perianal Crohn's disease after inducing remission with infliximab: how long should patients be treated? Aliment Pharmacol Ther. 2005;22(11-12):1107-1113.
                                                     
                                                    
                                                
                                                    
                                                        28	Farkas K, Lakatos PL, Nagy F, et al. Predictors of relapse in patients with ulcerative colitis in remission after one-year of infliximab therapy. Scand J Gastroenterol. 2013;48(12):1394-1398.
                                                     
                                                    
                                                
                                                    
                                                        29	Gandhi S, Jedel S, Hood MM, Mutlu E, Swanson G, Keshavarzian A. The relationship between coping, health competence and patient participation among patients with inactive inflammatory bowel disease. J Crohns Colitis. 2014;8(5):401-408.
                                                     
                                                    
                                                
                                                    
                                                        30	Guidi L, Ratto C, Semeraro S, et al. Combined therapy with infliximab and seton drainage for perianal fistulizing Crohn's disease with anal endosonographic monitoring: a single-centre experience. Tech Coloproctol. 2008;12(2):111-117.
                                                     
                                                    
                                                
                                                    
                                                        31	Liu ZX, Xiao MB, Wu XR, Queener E, Ni RZ, Shen B. Chronic pouchitis is associated with pouch polyp formation in patients with underlying ulcerative colitis. J Crohns Colitis. 2014;8(5):363-369.
                                                     
                                                    
                                                
                                                    
                                                        32	Louis E, Mary JY, Vernier-Massouille G, et al. Maintenance of remission among patients with Crohn's disease on antimetabolite therapy after infliximab therapy is stopped. Gastroenterology. 2012;142(1):63-70 e65; quiz e31.
                                                     
                                                    
                                                
                                                    
                                                        33	Lu C, Waugh A, Bailey RJ, et al. Crohn's disease genotypes of patients in remission vs relapses after infliximab discontinuation. World J Gastroenterol. 2012;18(36):5058-5064.
                                                     
                                                    
                                                
                                                    
                                                        34	Molnar T, Lakatos PL, Farkas K, et al. Predictors of relapse in patients with Crohn's disease in remission after 1 year of biological therapy. Aliment Pharmacol Ther. 2013;37(2):225-233.