Year 2023 / Volume 115 / Number 3
Letter
Glanzmann thrombasthenia: an uncommon cause of acute upper gastrointestinal bleeding

149

DOI: 10.17235/reed.2022.9081/2022

Raúl Alberto Jiménez Castillo, Daniel Eduardo Benavides-Salgado, Joel Omar Jáquez-Quintana, José Alberto González González, Carlos Alejandro Cortez Hernández, Homero Náñez-Terreros, Héctor Jesús Maldonado-Garza,

Abstract
The major function of platelets is to contribute to hemostasis. If an impairment in their production and/or function occurs, abnormal bleeding can develop. An 18-year-old male presented to our hospital after four episodes of hematemesis. His medical history was relevant for Glanzmann thrombasthenia diagnosed during early childhood. On initial examination, he appeared pale and with normal blood pressure. His complete blood count included a hemoglobin concentration of 11.0 g/dL, additional laboratory tests were within the normal ranges. The initial approach consisted of a high dose of proton pump inhibitors. Hours later, esophagogastroduodenoscopy revealed diffuse oozing bleeding from gastric mucosa with no other visible lesions such as peptic ulcers or varices
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References
1. Diz-Küçükkaya R. Inherited platelet disorders including Glanzmann thrombasthenia and Bernard-Soulier syndrome. Hematology Am Soc Hematol Educ Program. 2013; 2013:268-75.
2. Nurden AT, Pillois X. ITGA2B and ITGB3 gene mutations associated with Glanzmann thrombasthenia. Platelets. 2018; 29:98-101.
3. Franchini M, Favaloro EJ, Lippi G. Glanzmann thrombasthenia: an update. Clin Chim Acta. 2010; 411:1-6.
4. Grainger JD, Thachil J, Will AM. How we treat the platelet glycoprotein defects; Glanzmann thrombasthenia and Bernard Soulier syndrome in children and adults. Br J Haematol. 2018; 182:621-32.
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Citation tools
Jiménez Castillo R, Benavides-Salgado D, Jáquez-Quintana J, González González J, Cortez Hernández C, Náñez-Terreros H, et all. Glanzmann thrombasthenia: an uncommon cause of acute upper gastrointestinal bleeding. 9081/2022


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Publication history

Received: 13/07/2022

Accepted: 15/07/2022

Online First: 28/07/2022

Published: 07/03/2023

Article Online First time: 15 days

Article editing time: 237 days


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