Year 2022 / Volume 114 / Number 4
Original
Endoscopic retrograde cholangiopancreatography and carbohydrate antigen 19-9 in the differential diagnosis of biliary strictures

204-207

DOI: 10.17235/reed.2021.7711/2020

Lisset Barroso Márquez, Lissette Chao González, Marcia Samada Suárez, Harlim Rodríguez Rodríguez, Yunia Tusen Toledo, Kenia Valenzuela Aguilera, Teresita Pérez González,

Abstract
Introduction: bile-duct strictures include a wide spectrum of benign and malignant diseases. Objective: to determine the usefulness of endoscopic retrograde cholangio-pancreatography (ERCP) and circulating carbohydrate antigen 19-9 (CA 19-9) for the differential diagnosis of biliary strictures. Method: an observational, prospective, cross-sectional study was performed in 75 patients with biliary stricture diagnosed by ERCP between October 2018 and January 2020. The variables included type of biliary stricture as diagnosed by ERCP, biliary cytology, and CA 19-9 levels. For the statistical analysis, descriptive statistics were used according to type of variable. The relationships between them was analyzed using Pearson's chi-square and Fisher's exact probability tests, assuming differences were significant when p < 0.05. The cut-off point for CA 19-9 was calculated using the ROC curve, and Cohen's kappa index was used to measure concordance between diagnostic methods. Results: cytology was positive in 51 (68 %) patients with biliary stenosis. Mean age was 63 years. Acute cholangitis predominated in malignant strictures (93.7 %). There was agreement between cytology and the cut-off value calculated for CA 19-9 of 85.4 U/mL, with a kappa agreement index of 0.332 (p = 0.004), and between ERCP and cytology, with a kappa concordance index of 0.701 (p < 0.001). Conclusions: a serum CA 19-9 value higher than 85.4 U/mL is highly related to neoplastic biliary stenosis.
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Barroso Márquez L, Chao González L, Samada Suárez M, Rodríguez Rodríguez H, Tusen Toledo Y, Valenzuela Aguilera K, et all. Endoscopic retrograde cholangiopancreatography and carbohydrate antigen 19-9 in the differential diagnosis of biliary strictures . 7711/2020


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Publication history

Received: 07/12/2020

Accepted: 21/12/2020

Online First: 13/01/2021

Published: 07/04/2022

Article revision time: 10 days

Article Online First time: 37 days

Article editing time: 486 days


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