Year 2019 / Volume 111 / Number 11
Letter
Hepatocyte transplantation

896-897

DOI: 10.17235/reed.2019.6270/2019

Javier A. Cienfuegos, Fernando Rotellar, Víctor Valenti,

Abstract
We have read with great interest the study by Vera MC et al. on the intrasplenic transplantation of hepatocytes from donors receiving the carcinogenic drugs diethylnitrosamine (DEN) and 2-actylaminofluorene (2-AAF). The most important conclusion of the study is that there were no signs of tumor progression in the recipient liver at seven and 60 days after hepatocellular transplantation and no differences were found in the animals with healthy hepatocyte transplants.
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References
1. Vera MC , Biancardi ME , Bottai H , et al. First approaches on transplantatation of hepatocytes from Wistar rat preneoplastic livers into healthy recipients. Rev Espa Enferm Dig. 2019, In press May.
2. Cienfuegos JA, Rotellar F, Baixauli J, et al. Liver regeneration--the best kept secret. A model of tissue injury response. Rev. Esp. Enferm. Dig. 2014;106:171–94.
3. Nevzorova YA , Trauwein C. Liver regeneration. In: Boyer T, Wright TL, Manns MP, editors, Zakim and Boyer´shepatology: A textbook of liver disease. 6th ed. Philadelphia PA: Saunders/Elsevier, 2012.p:20–35.
4. Duncan AW. Aneuploidy, polyploidy and ploidy reversal in the liver. Semin. Cell Dev. Biol. 2013;24:347–56.
5. Shetty S, Lalor PF, Adams DH. Liver sinusoidal endothelial cells - gatekeepers of hepatic immunity. Nat. Rev. Gastroenterol. Hepatol. 2018;15:555–567.
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Cienfuegos J, Rotellar F, Valenti V. Hepatocyte transplantation. 6270/2019


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Publication history

Received: 08/03/2019

Accepted: 16/03/2019

Online First: 30/10/2019

Published: 07/11/2019

Article Online First time: 236 days

Article editing time: 244 days


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