Año 2004 / Volumen 96 / Número 3
Original
Estudio de las repercusiones en el íleon distal de la resección hepática parcial en la rata

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M. B. Rodríguez Sanz, J. Alarcón García, F. J. del Riego Tomás and C. Vaquero Puerta

Resumen
Introduction: hepatectomy, both partial resection and transplant, has greatly developed and advanced during the last years as a result of a better understanding of surgical anatomy and the progress
of technological means; it has also allowed a widening of surgical indications, including living-donor liver transplantation.
The aims of our study was to assess the morphological impact of partial hepatectomy on the distal ileum, since the liver and intestine behave as a unit from an anatomical, functional, and metabolic
point of view.

Material and methods: twenty-four Wistar rats were used; they were divided into two groups, a control and an experimental group (30, 90, and 180 days). We studied changes occurred in the distal ileum after a 70% liver resection, taking 4 parameters
into account.

Results: an important drop in total thickness occurred at the ileum wall in the experimental group (p < 0.001). There were no important differences in villus height with regard to the control group. Thickness at the villi fell significantly (p < 0.01), as did the depth of the crypts, which diminished significantly in relation to the control group (p < 0.001).

Conclusions: a 70% hepatectomy induces trophic changes on the distal ileum that remain in both the short and longer term, and causes atrophy of the ileum wall and a drop in villus thickness.
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M. B. Rodríguez Sanz, J. Alarcón García, F. J. del Riego Tomás and C. Vaquero Puerta. Estudio de las repercusiones en el íleon distal de la resección hepática parcial en la rata. 0


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