Year 2021 / Volume 113 / Number 6
Letter
Primary gastric adenocarcinoma in a patient with Peutz-Jeghers syndrome

474-475

DOI: 10.17235/reed.2020.7323/2020

Olga Ortega Lobete, Raquel Díaz Ruiz, Leticia Pérez Carazo,

Abstract
We present the case of a 42-year-old female under study due to dyspepsia without response to empirical treatment, with perioral mucocutaneous pigmentation. A gastroscopy revealed a 5 cm gastric tumor in the antrum, as well as multiple sessile gastric and duodenal polyps smaller than 1 cm. Large-capacity forceps biopsies were obtained and a well-differentiated adenocarcinoma with gastric origin was diagnosed, with over expression of the HER2/neu without microsatellite instability in the context of a hamartomatous polyposis. The genomic study confirmed an alteration in the STK11 gene translated to a truncated protein product, compatible with a Peutz-Jeghers syndrome (PJS).
Share Button
New comment
Comments
No comments for this article
References
Restaa N, Pierannunziob D, Lenato GN et al. Cancer risk associated with STK11/LKB1 germline mutations in Peutz–Jeghers syndrome patients: Results of an Italian multicenter study. Dig Liver Dis 2013; 45: 606–611
Katabathina VS, Menias CO, Khanna L et al. Hereditary Gastrointestinal Cancer Syndromes: Role of Imaging in Screening, Diagnosis, and Management. RadioGraphics 2019; 39:1280–1301
Pérez-Cuadrado-Robles E, Pinho R, González B et al. Small bowel enteroscopy – A joint clinical guideline by the Spanish and Portuguese small-bowel study groups. Rev Esp Enferm Dig 2020; 112(4):309-318
Pennazio M, Spada C, Eliakim R et al. Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline. Endoscopy 2015; 47: 352–376
Related articles

Letter

Blue rubber bleb nevus syndrome

DOI: 10.17235/reed.2023.9913/2023

Letter

Capsule endoscopy diagnosis of gastrointestinal melanoma

DOI: 10.17235/reed.2023.9803/2023

Letter

Isolated Jejunal Crohn's Disease: a challenging diagnosis

DOI: 10.17235/reed.2022.9423/2022

Digestive Diseases Image

Whipple’s disease – A typical endoscopic finding of a rare disease

DOI: 10.17235/reed.2022.9338/2022

Letter

Primary intestinal melanoma?

DOI: 10.17235/reed.2022.8944/2022

Digestive Diseases Image

An unusual finding in gastroesophageal surgery: gastric anthracosis

DOI: 10.17235/reed.2022.8882/2022

Digestive Diseases Image

Ileal neuroendocrine tumor as an uncommon cause of obscure gastrointestinal bleeding

DOI: 10.17235/reed.2022.8641/2022

Digestive Diseases Image

Duodenal-type follicular lymphoma: a silent tumor

DOI: 10.17235/reed.2021.8149/2021

Letter

Bochdalek hernia: use of capsule endoscopy

DOI: 10.17235/reed.2021.7760/2020

Digestive Diseases Image

Jejunal schwannoma detected by video capsule endoscopy

DOI: 10.17235/reed.2020.6474/2019

Digestive Diseases Image

Capsule endoscopy, a useful tool for the diagnosis of a tapeworm infection

DOI: 10.17235/reed.2019.6346/2019

Letter

Use of patency capsule in daily practice

DOI: 10.17235/reed.2019.5952/2018

Digestive Diseases Image

Metastasis of dermatofibrosarcoma diagnosed by capsule endoscopy

DOI: 10.17235/reed.2018.4900/2017

Letter to the Editor

Symptomatic retention of the Agile® patency capsule

DOI: 10.17235/reed.2017.4691/2016

Letter to the Editor

Whipple’s disease under the vision of capsule endoscopy

DOI: 10.17235/reed.2016.4362/2016

Letter to the Editor

Asymptomatic bronchial aspiration of capsule endoscope: a significant complication

DOI: 10.17235/reed.2016.4363/2016

Case Report

Atypical diagnosis diagnosis by endoscopic capsule: Whipple´s disease

DOI: 10.17235/reed.2015.3718/2015

Letter to the Editor

Synchronic gastric and pancreatic ductal adenocarcinoma. A case report

DOI: 10.17235/reed.2015.3720/2014

Citation tools
Ortega Lobete O, Díaz Ruiz R, Pérez Carazo L. Primary gastric adenocarcinoma in a patient with Peutz-Jeghers syndrome. 7323/2020


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 418 visits.
This article has been downloaded 106 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 08/06/2020

Accepted: 11/08/2020

Online First: 27/11/2020

Published: 04/06/2021

Article Online First time: 172 days

Article editing time: 361 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology