Year 2025 / Volume 117 / Number 7
Letter
Derived neutrophil-to-lymphocyte ratio (dNLR) as a diagnostic biomarker of pediatric acute appendicitis

418-419

DOI: 10.17235/reed.2024.10497/2024

Julio César Moreno-Alfonso, Sharom Barbosa Velásquez, Sara Mesa Helguera, Ada Molina Caballero, María Concepción Yárnoz Irazábal, Alberto Pérez Martínez,

Abstract
Appendicitis stands as the most common surgical emergency in pediatric populations. Despite the existence of numerous diagnostic biomarkers, their utility is constrained by limitations in cost-effectiveness, potentially leading to therapeutic delays. This research aims to determine the diagnostic accuracy of the derived neutrophil-to-lymphocyte ratio (dNLR) in appendicitis. Although its role in this context has been recently described, this is the first study to compare its performance against acute-phase reactants routinely employed in clinical practice. Following approval from the Research Committee (2023/390894), a diagnostic study was conducted including patients under 15 years old undergoing surgery for acute appendicitis (AA) and those presenting with non-surgical abdominal pain (AP).
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References
1. Martínez-Criado Y, Millán-López A, Galán N, De-Agustín-Asensio JC. Acute appendicitis by Enterobius vermicularis, an unusual etiology in children. Rev Esp Enferm Dig 2012;104(7):393-4. DOI: 10.4321/s1130-01082012000700016
2. Echevarria S, Rauf F, Hussain N, et al. Typical and Atypical Presentations of Appendicitis and Their Implications for Diagnosis and Treatment: A Literature Review. Cureus 2023;15:e37024. DOI: 10.7759/cureus.37024
3. Moreno-Alfonso JC, Molina A, Pérez A. Usefulness of cell ratios and the derived neutrophil-to-lymphocyte ratio in the diagnosis of pediatric acute appendicitis. Cir Pediatr 2024;37:11-16. DOI: 10.54847/cp.2024.01.11
4. Moreno-Alfonso JC, Molina A, Yárnoz MC, Pérez A. Blood cell indices as predictors of complicated appendicitis: A diagnostic study. Journal of Pediatric Surgery Open 2023;4:100072. DOI: https://doi.org/10.1016/j.yjpso.2023.100072
5. Uz B. The Prognostic Value of the Derived Neutrophil-to-Lymphocyte Ratio in Transplantation-Ineligible Patients with Multiple Myeloma. Acta Haematol. 2018;140:157-158. DOI: 10.1159/000491988
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Moreno-Alfonso J, Barbosa Velásquez S, Mesa Helguera S, Molina Caballero A, Yárnoz Irazábal M, Pérez Martínez A, et all. Derived neutrophil-to-lymphocyte ratio (dNLR) as a diagnostic biomarker of pediatric acute appendicitis. 10497/2024


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Publication history

Received: 20/04/2024

Accepted: 30/04/2024

Online First: 20/05/2024

Published: 08/07/2025

Article Online First time: 30 days

Article editing time: 444 days


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