Año 2021 / Volumen 113 / Número 7
Original
High expression of NDRG3 correlates with poor prognosis in gastric cancer patients

524-528

DOI: 10.17235/reed.2021.7723/2020

Yun Liu, Jinxuan Xia, Yong Zhou, Shihe Shao,

Resumen
Introduction: N-myc downstream-regulated gene 3 (NDRG3) is an important member of the NDRG family and is linked with malignant tumors. However, the relationship between NDRG3 and gastric cancer (GC) is vague. Material and methods: Western blot, qRT-PCR and immunohistochemistry (IHC) detected the expression of NDRG3 in GC cell lines and GC tissues; public databases were used to analyze NDRG3 in GC patients and the association with EBV infection. Results: NDRG3 was up-regulated in GC cell lines and tissues. IHC data suggested that NDRG3 was correlated with histologic grade (p = 0.006) and is associated with patient survival. Discussion: thus, NDRG3 may be a novel predictor of GC prognosis.
Share Button
Nuevo comentario
Comentarios
No hay comentarios para este artículo.
Bibliografía
[1]Fang J, Wang H, Liu Y, et al. High KRT8 expression promotes tumor progression and metastasis of gastric cancer. Cancer Sci 2017;108(2):178–86.
[2]Liu Y, Shao C, Zhu LQ, et, al. High Expression of ABL2 Suppresses Apoptosis in Gastric Cancer. Dig Dis Sci 2018;63(9):2294-00.
[3] Karimi P, Islami F, Anandasabapathy S, et al. Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention. Cancer Epidemiol Biomarkers Prev 2014;23(5):700–13.
[4] Yoon H, Kim N. Diagnosis and management of high risk group for gastric cancer. Gut Liver 2015;9(1):5–17.
[5] Wang F, Meng W, Wang B, et al. Helicobacter pylori-induced gastric inflammation and gastric cancer. Cancer Lett 2014;10;345(2):196-202.
[6] Shimizu T, Marusawa H, Watanabe N, et al. Molecular Pathogenesis of Helicobacter pylori-Related Gastric Cancer. Gastroenterol Clin North Am 2015;44(3):625-38.
[7] Guggenheim DE, Shah MA. Gastric cancer epidemiology and risk factors. J Surg Oncol. 2013;107(3):230-6.
[8] Johnston FM, Beckman M. Updates on Management of Gastric Cancer. Curr Oncol Rep. 2019;21(8):67.
[9] Yu J, Shen J, Qiao X, et al. The SNHG20 / miR-140-5p / NDRG3 axis contributes to resistance to 5-fluorouracil in gastric cancer. Oncol Lett 2019; 18 (2): 1337-43.
[10] Yu C, Hao X, Zhang S, et al. Characterization of the prognostic values of the NDRG family in gastric cancer. Therapeutic advances in gastroenterology. January 2019.
[11] Kim MC, Park MH, Kang SH, et al. NDRG3 protein expression is associated with aggressive biologic phenotype and unfavorable outcome in patients with invasive breast cancer. Int J Clin Exp Pathol. 2019 ;12(10):3886-93.
[12] Estiar MA, Zare AA, Esmaeili R, et al. Clinical significance of NDRG3 in patients with breast cancer. Future Oncol. 2017;13(11):961-9.
[13] Jing JS, Li H, Wang SC, et al. NDRG3 overexpression is associated with a poor prognosis in patients with hepatocellular carcinoma. Biosci Rep. 2018;38(6):BSR20180907.
[14] Okuda T, Kondoh H. Identification of new genes ndr2 and ndr3 which are related to Ndr1/RTP/Drg1 but show distinct tissue specificity and response to N-myc. Biochem Biophys Res Commun 1999;266(1): 208-15.
Artículos relacionados

Original

Can we optimize CEA as a response marker in rectal cancer?

DOI: 10.17235/reed.2020.7321/2020

Carta

Primary squamous cell carcinoma of the stomach: a rare entity

DOI: 10.17235/reed.2018.5900/2018

Editorial

El reto del colon derecho

DOI: 10.17235/reed.2018.5544/2018

Carta al Editor

Tumores neuroendocrinos de páncreas: claves para afrontar la heterogeneidad

DOI: 10.17235/reed.2017.4997/2017

Carta al Editor

Tumores neuroendocrinos de páncreas: factores pronósticos

DOI: 10.17235/reed.2017.5109/2017

Editorial

Tumores neuroendocrinos del páncreas: no tan raros y no tan benignos

DOI: 10.17235/reed.2016.4672/2016

Instrucciones para citar
Liu Y, Xia J, Zhou Y, Shao S. High expression of NDRG3 correlates with poor prognosis in gastric cancer patients . 7723/2020


Descargar en un gestor de citas

Descargue la cita de este artículo haciendo clic en uno de los siguientes gestores de citas:

Métrica
Este artículo ha sido visitado 646 veces.
Este artículo ha sido descargado 108 veces.

Estadísticas de Dimensions


Estadísticas de Plum Analytics

Ficha Técnica

Recibido: 12/12/2020

Aceptado: 27/01/2021

Prepublicado: 10/02/2021

Publicado: 07/07/2021

Tiempo de revisión del artículo: 42 días

Tiempo de prepublicación: 60 días

Tiempo de edición del artículo: 207 días


Compartir
Este artículo aun no tiene valoraciones.
Valoración del lector:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
La REED es el órgano oficial de la Sociedad Española de Patología Digestiva, la SociedadEspañola de Endoscopia Digestiva y la Asociación Española de Ecografía Digestiva
Política de cookies Política de Privacidad Aviso Legal © Copyright 2023 y Creative Commons. Revista Española de Enfermedades Digestivas