Year 2025 / Volume 117 / Number 8
Letter
Brief description of Mendelian randomized studies

484-485

DOI: 10.17235/reed.2024.10917/2024

Joaquín González Aroca,

Abstract
Mendelian randomization (MR) offers a more rigorous framework than traditional observational studies by using genetic variants to assess causal relationships. Three critical assumptions are necessary for MR validity: relevance, independence, and exclusion restriction. These assumptions ensure that the genetic variants accurately reflect the risk factor's impact on the outcome. By elucidating these key points, this article aims to enhance understanding of MR's strengths and limitations in epidemiological research.
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References
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Publication history

Received: 04/11/2024

Accepted: 15/11/2024

Online First: 26/11/2024

Published: 24/07/2025

Article Online First time: 22 days

Article editing time: 262 days


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