Year 2026 / Volume 118 / Number 2
Letter
Post-endoscopic retrograde cholangiopancreatography bowel evisceration in a liver transplant recipient previously treated with atezolizumab-bevacizumab: first report

109-110

DOI: 10.17235/reed.2025.11518/2025

Elena Santos-Pérez, Cecile Gomercic, Maxime Thobois, Anne-Claire Frin, Dann Ouizeman, Geoffroy Vanbiervliet, Michel Rayar, Rodolphe Anty,

Abstract
Hepatocellular carcinoma (HCC) treatment increasingly involves liver transplantation (LT), often after downstaging therapies. Atezolizumab, a PD-L1 inhibitor, combined with bevacizumab, an anti-VEGF agent, is widely used, showing high response rates pre-transplant. However, bevacizumab impairs angiogenesis and can significantly increase the risk of wound dehiscence, infection, and delayed healing after major surgery, including LT.
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References
1. Singal, Amit G et al. “AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma.” Hepatology (Baltimore, Md.) vol. 78,6 (2023): 1922-1965.
2. Tabrizian, Parissa et al. “Neoadjuvant atezolizumab plus bevacizumab prior liver transplantation for hepatocellular carcinoma.” JHEP reports : innovation in hepatology vol. 7,2 101246. 18 Oct. 2024,
3. Rezaee-Zavareh, Mohammad Saeid et al. “Impact of pre-transplant immune checkpoint inhibitor use on post-transplant outcomes in HCC: A systematic review and individual patient data meta-analysis.” Journal of hepatology vol. 82,1 (2025): 107-119.
4. Kohli, Divyanshoo R et al. “American Society for Gastrointestinal Endoscopy guideline on management of post-liver transplant biliary strictures: summary and recommendations.” Gastrointestinal endoscopy vol. 97,4 (2023): 607-614.
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Citation tools
Santos-Pérez E, Gomercic C, Thobois M, Frin A, Ouizeman D, Vanbiervliet G, et all. Post-endoscopic retrograde cholangiopancreatography bowel evisceration in a liver transplant recipient previously treated with atezolizumab-bevacizumab: first report. 11518/2025


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Publication history

Received: 21/07/2025

Accepted: 22/09/2025

Online First: 23/10/2025

Published: 09/02/2026

Article Online First time: 94 days

Article editing time: 203 days


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