Año 2019 / Volumen 111 / Número 11
Original
Prognostic value of serum high-density lipoprotein cholesterol in patients with gallbladder cancer

839-845

DOI: 10.17235/reed.2019.6201/2019

Bo Yuan, Jing Fu, Wen-Long Yu, Xiao-Hui Fu, Ying-He Qiu, Lei Yin, Bin Zhu, Yong-Jie Zhang,

Resumen
Objectives: the aim of this study was to evaluate the prognostic significance of preoperative serum lipid in patients with gallbladder cancer (GBC). Methods: ninety-nine patients with GBC between October 2009 and December 2013 were reviewed in this retrospective study. Total serum cholesterol (TC), total triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A (Apo-A), apolipoprotein B (Apo-B) and free fatty acids (FFA) were measured before surgery. The correlation of serum lipid levels with clinical data, including gender, age, tumor size, lymph nodes metastasis, tumor differentiation, distant metastasis and TNM stage were analyzed by univariate and multivariate survival analysis to evaluate independent prognostic factors. Results: compared with the normal HDL-C group (n = 57), the overall survival rate among GBC patients with low HDL-C levels (n = 42) was reduced (p < 0.05). However, there were no significant differences in overall survival for patients with different levels of TC, TG, Apo-A, Apo-B, LDL-C or FFA. The serum level of HDL-C was associated with TNM stage (p < 0.05) and distant metastasis (p < 0.001). The multivariate prognosis analysis showed that HDL-C and lymph nodes metastasis were independent prognostic factors (p < 0.05). A prognostic evaluation model based on HDL-C and lymph nodes metastasis was established. Conclusion: preoperative serum HDL-C level was closely associated with distant metastasis of patients with GBC. HDL-C level may be a valuable prognostic factor for GBC patients. The combination of HDLC and lymph nodes metastasis can better predict the prognosis of GBC.
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Bibliografía
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Yuan B, Fu J, Yu W, Fu X, Qiu Y, Yin L, et all. Prognostic value of serum high-density lipoprotein cholesterol in patients with gallbladder cancer. 6201/2019


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Ficha Técnica

Recibido: 30/01/2019

Aceptado: 26/04/2019

Prepublicado: 09/10/2019

Publicado: 07/11/2019

Tiempo de revisión del artículo: 80 días

Tiempo de prepublicación: 252 días

Tiempo de edición del artículo: 281 días


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