Year 2006 / Volume 98 / Number 9
Original
Gastric MALT lymphoma: clinical characteristics and prevalence of H. pylori infection in a series of 37 cases

pp. 655-665

J. P. Gisbert, B. Aguado, M. Luna, S. Nistal, L. M. Asenjo, T. Reina, A. Acevedo and R. Arranz

Abstract
Objective: to perform a retrospective review of the clinical characteristics and prevalence of H. pylori infection in patients with gastric MALT lymphoma diagnosed in our hospital during the last 15 years.

Methods: patients with gastric MALT lymphoma diagnosed in our hospital during the last 15 years were retrospectively included.
Demographic, clinic, analytic, endoscopic, and histological variables were reviewed. The extension study, the staging classification, and the presence of H. pylori infection were assessed.

Results: thirty-seven patients with gastric MALT lymphoma were identified. Mean age was 61 years, with 62% of males. The most common presentation symptom was dyspepsia (76%), followed
by digestive bleeding (11%) and constitutional syndrome (8%). At endoscopy, erosive lesions were identified in 41%, and proliferative or exophytic lesions in 43%. Most lymphomas were
classified as low-grade (68%). The stage distribution was EI for 56%, EII for 13%, EIII for 3%, and EIV for 28%. The prevalence of H. pylori infection (histology in all cases, rapid urease test in
19%, and 13C-urea breath test in 24%) was 46%. When only lowgrade lymphomas in stage EI were considered, H. pylori prevalence increased to 55%. When H. pylori infection was evaluated
by 13C-urea breath testing (in addition to histology), the prevalence of H. pylori infection increased to 78%.

Conclusions: it is probable that the reduced H. pylori prevalence found in some studies, as in ours, could be explained by false-negative results obtained when only one diagnostic method
was used. Therefore, at least two (invasive) diagnostic methods should be performed. Furthermore, the performance of a non-invasive
diagnostic method (such as a 13C-urea breath test) before the exclusion of H. pylori infection should be considered.
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J. P. Gisbert, B. Aguado, M. Luna, S. Nistal, L. M. Asenjo, T. Reina, A. Acevedo and R. Arranz. Gastric MALT lymphoma: clinical characteristics and prevalence of H. pylori infection in a series of 37 cases. 655-665


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