Year 2020 / Volume 112 / Number 8
Letter
The development of type-1 autoimmune hepatitis after chronic hepatitis C (HCV) clearance by direct-acting antivirals (DAA)

664-665

DOI: 10.17235/reed.2020.6785/2019

Cristina Montón, M.ª Desamparados Escudero, Isabel Pascual,

Abstract
We present the case of a 72-year-old female in follow-up for chronic hepatitis due to hepatitis C virus (HCV) genotype 1b, with a liver stiffness measurement estimated by transient elastography in 2015 of 17 Kp and type 2 diabetes mellitus. She was treated daily with ledipasvir 90 mg and sofosbuvir 400 mg for 12 weeks. In March 2016, she achieved a sustained virological response (SVR) after 12 weeks and 24 weeks. She had a positive determination of antinuclear antibodies 7.9 in 2014.
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References
1. Covini G, Bredi E, Badalamenti S, et al. Autoimmune Hepatitis During Ledipasvir/Sofosbuvir Treatment of Hepatitis C: A Case Report. Hepatol Commun. 2018 Sep 25;2(10):1179-1183. doi: 10.1002/hep4.1248. eCollection 2018 Oct.
2. Matsumoto K, Kikuchi K, Kajiyama Y, et al . Development of Autoimmune Hepatitis during Direct-acting Antiviral Therapy for Chronic Hepatitis C Virus Infection. Intern Med. 2018 Sep 15;57(18):2669-2673. doi:10.2169/internalmedicine.0613-17. Epub 2018 Apr 27.
3. Efe C, Heurgué-Berlot A, Ozaslan E et al. Late autoimmune hepatitis after hepatitis C therapy. Eur J gastroenterol Hepatol 2013 Nov;25(11):1308-11. doi: 10.1097/MEG.0b013e328361c704.
4. Terziroli Beretta-Piccoli B, Di Bartolomeo C, Deleonardi G, et al, Hepatitis C Cohort Study. Autoimmune liver serology before and after successful treatment of chronic hepatitis C by direct acting antiviral agents. J Autoimmun. 2019 Aug;102:89-95. doi: 10.1016/j.jaut.2019.04.019.
5. López Couceiro L, Gómez Domínguez E, Muñoz Gómez R et al. Healing of autoimmune hepatitis associated with hepatitis C virus infection treated with direct-acting antivirals. Rev Esp Enferm Dig. 2019 Feb;111(2):159-161. doi: 10.17235/reed.2018.5528/2018.
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Montón C, Escudero M, Pascual I. The development of type-1 autoimmune hepatitis after chronic hepatitis C (HCV) clearance by direct-acting antivirals (DAA). 6785/2019


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Publication history

Received: 02/12/2019

Accepted: 27/12/2019

Online First: 20/07/2020

Published: 30/07/2020

Article revision time: 21 days

Article Online First time: 231 days

Article editing time: 241 days


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