Year 2024 / Volume 116 / Number 4
Letter
KRAS mutations in pancreatic cancer: could we talk about a risk factor for the development of thromboembolic phenomena?

236-237

DOI: 10.17235/reed.2023.9926/2023

César Gutiérrez Pérez, Carmen Blanco Abad, Gadea Hontoria Bautista, Patricia Saiz López, Inmaculada Rodríguez Ledesma, Noelia Espinosa Cabria, Irene Ramos Reguera, Ana María López Muñoz,

Abstract
The oncogenic KRAS mutation is associated with increased tissue factor expression and thus hypercoagulability. In this regard, numerous studies published in the last decade have shown that KRAS mutations are an important risk factor for the development of thromboembolic phenomena in neoplasms of the digestive tract, such as colorectal cancer. On the other hand, some recently published studies suggest that KRAS mutations are also associated with an increased risk of developing thromboembolic phenomena in pancreatic cancer. Based on these premises, we have conducted a single-centre retrospective study on a cohort of patients with pancreatic cancer. Our aim is to demonstrate whether there is an association between the presence of KRAS mutations in our cohort of pancreatic cancer patients and an increased risk of developing thromboembolic phenomena.
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References
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Citation tools
Gutiérrez Pérez C, Blanco Abad C, Hontoria Bautista G, Saiz López P, Rodríguez Ledesma I, Espinosa Cabria N, et all. KRAS mutations in pancreatic cancer: could we talk about a risk factor for the development of thromboembolic phenomena?. 9926/2023


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Publication history

Received: 31/08/2023

Accepted: 13/09/2023

Online First: 29/09/2023

Published: 09/04/2024

Article Online First time: 29 days

Article editing time: 222 days


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