Year 2024 / Volume 116 / Number 4
Original
Is long-term follow-up solely by imaging tests safe in non-operated pancreatic neuroendocrine tumors?

209-215

DOI: 10.17235/reed.2023.9293/2022

Daniela Polette, Juli Busquets, Lluis Secanella Medayo, Maria Sorribas Grifell, Núria Peláez Serra, Catalina Uribe, Laura Martinez-Carnicero, Silvia Salord Vila, Fernando Guerrero, Jose Luis Vercher-Conejero, Alex Teulé, Joan Fabregat,

Abstract
Introduction: the diagnosis of asymptomatic sporadic nonfunctioning pancreatic neuroendocrine tumors (NF-PNETs) has increased significantly due to the widespread use of high-resolution imaging tests, which is why the most appropriate management at the time of diagnosis is the subject of debate, as is how to follow-up patients. Aims: the objective of this study was to analyze the frequency of imaging and endoscopic studies performed during long-term follow-up. Methods: a retrospective review was performed of a database collected between January 2008 and December 2020 of patients with an incidental diagnosis of small NF-PNETs; follow-up was closed in March 2023. The imaging tests performed at the time of diagnosis and long-term follow-up were recorded. Growing less than 1 mm per year has not been considered as a worrisome feature. Follow-up was performed through imaging tests, considering endoscopic cytology for lesions with a faster grow rate. Results: fifty-eight patients were included; the median age was 69 years. The initial mean size of the lesions studied was 12.79 mm (5-27). Follow-up was carried out only with computed tomography (CT) or magnetic resonance imaging (MRI). The initial size did not influence the behavior of the lesion in a statistically significant manner. Twenty-eight tumors (45 %) increased in size, with a growth equal to or less than 4 mm in 24 cases. The mean follow-up time was 82.41 months (12-164). No patient developed metastasis or died from PNET progression. Conclusions: the follow-up of neuroendocrine tumors of small size can be performed safely with only imaging tests.
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Polette D, Busquets J, Secanella Medayo L, Sorribas Grifell M, Peláez Serra N, Uribe C, et all. Is long-term follow-up solely by imaging tests safe in non-operated pancreatic neuroendocrine tumors?. 9293/2022


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Publication history

Received: 19/10/2022

Online First: 27/11/2023

Published: 09/04/2024

Article Online First time: 404 days

Article editing time: 538 days


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