Year 2019 / Volume 111 / Number 1
Letter
Fulminant liver failure secondary to submassive hepatic necrosis in a patient treated with Orlistat. A case report

83

DOI: 10.17235/reed.2018.5740/2018

Luis Alberto Martínez Insfran, Felipe Alconchel Gago, Pascual Parrilla Paricio,

Abstract
Orlistat is an intestinal lipase inhibitor drug that is recommended in obese patients along with a hypocaloric diet. Although the most frequent secondary effect is steatorrhea, fulminant liver failure has also been associated with this drug, which has required liver transplantation in 3 patients. We present the case of a 42-year-old obese male.
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References
1. Torgerson JS, Boldrin MN, Hauptman J, Sjöström L. XENical in the prevention of diabetes in obese subjects (XENDOS) study. Diabetes Care 2004; 27: 155–161.
2. Montero JL, Muntane J, Fraga E et al. Orlistat associated subacute hepatic failure. J Hepatol 2001; 34: 173–179.
3. Thurairajah PH, Syn WK, Neil DA, Stell D, Haydon G. Orlistat (Xenical)-induced subacute liver failure. Eur J Gastroenterol Hepatol 2005; 17: 1437–1438.
4. Wilson NS, Shah N, Manitpisitkul W et al. Liver failure requiring transplantation after orlistat use. Pharmacotherapy 2011; 31: 492–495.
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Martínez Insfran L, Alconchel Gago F, Parrilla Paricio P. Fulminant liver failure secondary to submassive hepatic necrosis in a patient treated with Orlistat. A case report. 5740/2018


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Publication history

Received: 22/05/2018

Accepted: 13/06/2018

Online First: 16/10/2018

Published: 17/01/2019

Article Online First time: 147 days

Article editing time: 240 days


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