Year 2019 / Volume 111 / Number 4
Letter
Duodenal villous atrophy with a negative serology induced by mycophenolate mofetil: not everything is celiac disease

330-331

DOI: 10.17235/reed.2018.5907/2018

Javier Lucas Ramos, Pedro de María Pallarés, Álvaro Pezzela Risueño,

Abstract
Mycophenolate mofetil (MMF) is an immunosuppressive agent that is used in transplanted patients, with frequent gastrointestinal adverse effects. We report the case of a patient, under chronic therapy with mycophenolate mofetil , during a diagnostic workup for a chronic diarrhea, which presents a duodenal villous atrophy ( VA) with negative celiac serology, which is a diagnostic challenge. VA secondary to MMF is a very unusual adverse effect. Just a few cases have been reported in the literature.
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References
1.Degaetani M, Tennyson CA, Lebwohl B, Lewis SK, Abu Daya H, Arguelles-Grande C, et al. Villous atrophy and negative celiac serology: A diagnostic and therapeutic dilemma. Am J Gastroenterol . 2013;108(5):647–53.
2. Mendoza-Chuctaya Giuston, Nieto-Portocarrero Rubén. Atrofia vellositaria duodenal causado por el micofenolato de mofetilo en pacientes con trasplante de órgano sólido: reporte de un caso. Horiz. Med. . 2016 Jul; 16( 3 ): 76-78
3. Tapia E O, Villaseca H M, Sierralta Z A, Roa S JC. Atrofia vellositaria duodenal inducida por micofenolato mofetil: Caso cl??nico. Rev Med Chil. 2010;138(5):590–4.
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Lucas Ramos J, de María Pallarés P, Pezzela Risueño Á. Duodenal villous atrophy with a negative serology induced by mycophenolate mofetil: not everything is celiac disease. 5907/2018


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Publication history

Received: 05/09/2018

Accepted: 15/09/2018

Online First: 04/12/2018

Published: 04/04/2019

Article Online First time: 90 days

Article editing time: 211 days


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