Year 2021 / Volume 113 / Number 4
Original
Outcomes of drug-induced acute pancreatitis: a ten-year experience of an academic center

276-279

DOI: 10.17235/reed.2020.7443/2020

Rubén Sánchez-Aldehuelo, Ana García García de Paredes, Diego Rojo Lázaro, Antonio Martínez Ortega, Irene García de la Filia Molina, Sergio López-Durán, Miguel Ángel Rodríguez-Gandía, Antonio López-Sanromán, Agustín Albillos,

Abstract
Background: drug-induced pancreatitis is an unexplored entity. Methods: a retrospective cohort study was performed at a referral center. Patients with drug-induced acute pancreatitis between 2008 and 2018 were included. Baseline patient characteristics, involved drugs, clinical course and recurrence were analyzed. Results: drug-induced pancreatitis represented 2.8 % of acute pancreatitis (47/1,665) and 18 different drugs were involved (thiopurines 61.8 %). The latency period was less than one month in 87.2 % of cases. Pancreatitis was mild in 89.3 % and recurrence risk was 2.3 %. Conclusion: drugs are a rare cause of pancreatitis, which mostly occurs within the first month of treatment, is usually mild and is associated with a low risk of recurrence.
Share Button
New comment
Comments
No comments for this article
References
1. Wadhwa V, Patwardhan S, Garg SK, et al. Health Care Utilization and Costs Associated With Acute Pancreatitis. Pancreas. 2017;46(3):410-5.
2. Simons-Linares CR, Elkhouly MA, Salazar MJ. Drug-Induced Acute Pancreatitis in Adults: An Update. Pancreas. 2019;48(10):1263-73.
3. Chung EK, Lee JH, Jang DK, et al. Causative Agents of Drug-Induced Pancreatitis: A Nationwide Assessment. Pancreas. 2018;47(10):1328-36.
4. Nitsche C, Maertin S, Scheiber J, et al. Drug-induced pancreatitis. Curr Gastroenterol Rep. 2012;14(2):131-8.
5. Jones MR, Hall OM, Kaye AM, et al. Drug-induced acute pancreatitis: a review. Ochsner J. 2015;15(1):45-51.
6. Hung WY, Abreu Lanfranco O. Contemporary review of drug-induced pancreatitis: A different perspective. World J Gastrointest Pathophysiol. 2014;5(4):405-15.
7. Tenner S, Baillie J, DeWitt J, et al. American College of Gastroenterology guideline: management of acute pancreatitis. Am J Gastroenterol. 2013;108(9):1400-15; 16.
8. Working Group IAPAPAAPG. IAP/APA evidence-based guidelines for the management of acute pancreatitis. Pancreatology. 2013;13(4 Suppl 2):e1-15.
9. Badalov N, Baradarian R, Iswara K, et al. Drug-induced acute pancreatitis: an evidence-based review. Clin Gastroenterol Hepatol. 2007;5(6):648-61; quiz 4.
10. Razavi D, Lindblad M, Bexelius T, et al. Polypharmacy and risk of acute pancreatitis. Pharmacoepidemiol Drug Saf. 2016;25(11):1337-41.
11. Vinklerova I, Prochazka M, Prochazka V, et al. Incidence, severity, and etiology of drug-induced acute pancreatitis. Dig Dis Sci. 2010;55(10):2977-81.
12. Bermejo F, Lopez-Sanroman A, Taxonera C, et al. Acute pancreatitis in inflammatory bowel disease, with special reference to azathioprine-induced pancreatitis. Aliment Pharmacol Ther. 2008;28(5):623-8.
13. Weersma RK, Peters FT, Oostenbrug LE, et al. Increased incidence of azathioprine-induced pancreatitis in Crohn's disease compared with other diseases. Aliment Pharmacol Ther. 2004;20(8):843-50.
14. Tenner S. Drug induced acute pancreatitis: does it exist? World J Gastroenterol. 2014;20(44):16529-34.
Related articles

Digestive Diseases Image

Spontaneous duodenal wall hematoma

DOI: 10.17235/reed.2023.9793/2023

Letter

Anemia can predict organ failure in acute pancreatitis

DOI: 10.17235/reed.2023.9700/2023

Letter

Colon necrosis in acute severe pancreatitis

DOI: 10.17235/reed.2022.9263/2022

Letter

Disconnected pancreatic duct syndrome. Endoscopic approach

DOI: 10.17235/reed.2022.9261/2022

Letter

The enigmatic triad, a clinical challenge

DOI: 10.17235/reed.2022.9212/2022

Letter

Spontaneous drainage of a pancreatic pseudocyst into the stomach

DOI: 10.17235/reed.2022.8999/2022

Editorial

Acute pancreatitis: an opportunity for gastroenterology hospitalists?

DOI: 10.17235/reed.2022.8573/2022

Digestive Diseases Image

Endoscopic necrosectomy – when the gastroenterologist faces his greatest nightmare.

DOI: 10.17235/reed.2021.8403/2021

Digestive Diseases Image

Wunderlich syndrome secondary to severe acute pancreatitis

DOI: 10.17235/reed.2021.8184/2021

Digestive Diseases Image

Emphysematous pancreatitis: a rare entity with characteristic radiological findings

DOI: 10.17235/reed.2021.8093/2021

Letter

Acute pancreatitis related to SARS-CoV-2 infection. Disclaimer

DOI: 10.17235/reed.2021.7853/2021

Letter

Pancreatic injury and acute pancreatitis in COVID-19 patients

DOI: 10.17235/reed.2021.7807/2021

Letter

Pancreatic injury in COVID-19: pathogenesis and challenges

DOI: 10.17235/reed.2020.7541/2020

Letter

SARS-CoV-2 and acute pancreatitis: a new etiological agent?

DOI: 10.17235/reed.2020.7481/2020

Letter

Bortezomib-induced acute pancreatitis, an uncommon adverse event

DOI: 10.17235/reed.2020.7120/2020

Editorial

Guessing the future of endoscopic drainage of walled-off necrosis

DOI: 10.17235/reed.2020.7252/2020

Letter

Problems with a prophylactic non-expulsive pancreatic stent

DOI: 10.17235/reed.2020.7001/2020

Letter

Viral infection and pediatric pancreatitis

DOI: 10.17235/reed.2020.6933/2020

Digestive Diseases Image

Groove pancreatitis: a rare cause of severe gastric dilation

DOI: 10.17235/reed.2020.6765/2019

Letter

Acute pancreatitis associated with levofloxacin

DOI: 10.17235/reed.2020.6652/2019

Digestive Diseases Image

Endoscopic therapy in disconnected duct syndrome: re-connecting the duct

DOI: 10.17235/reed.2020.6650/2019

Digestive Diseases Image

Colon perforation due to fistulization of a pancreatic pseudocyst

DOI: 10.17235/reed.2018.5884/2018

Digestive Diseases Image

A rare case of acute obstructive suppurative pancreatic ductitis associated with ERCP

DOI: 10.17235/reed.2018.5756/2018

Editorial

Pancreatic stents in ERCP. Where are we?

DOI: 10.17235/reed.2018.5670/2018

Letter to the Editor

Tender red subcutaneous nodules in an adult female: a challenging diagnosis

DOI: 10.17235/reed.2018.5472/2018

Letter to the Editor

Idiopathic portal hypertension with regard to thiopurine treatment

DOI: 10.17235/reed.2018.5256/2017

Letter to the Editor

A patient with Castleman’s disease mimicking acute pancreatitis

DOI: 10.17235/reed.2017.5120/2017

Letter to the Editor

Abdominal compartment syndrome secondary to acute necrotizing pancreatitis

DOI: 10.17235/reed.2017.4810/2016

Letter to the Editor

Genetics in idiopathic pancreatitis and acute recurrent pancreatitis

DOI: 10.17235/reed.2017.4632/2016

Original

Mercaptopurine and inflammatory bowel disease: the other thiopurine

DOI: 10.17235/reed.2016.4546/2016

Letter to the Editor

Hemobilia related to cystic artery pseudoaneurysm as a cause of acute pancreatitis

DOI: 10.17235/reed.2017.4532/2016

Letter to the Editor

Xanthogranulomatous pancreatitis: a lesion that mimics pancreatic cancer

DOI: 10.17235/reed.2017.4496/2016

Letter to the Editor

Intramural gastric hematoma in the context of an acute pancreatitis

DOI: 10.17235/reed.2017.4494/2016

Case Report

Case of drug-induced acute pancreatitis produced by horsetail infusions

DOI: 10.17235/reed.2017.4157/2015

Case Report

Pseudoaneurysm associated with complicated pancreatic pseudocysts

DOI: 10.17235/reed.2016.3855/2015

Case Report

Olanzapine-induced ischemic colitis

DOI: 10.17235/reed.2015.3856/2015

Case Report

Acute hemorrhagic necrotizing pancreatitis in falciparum malaria

DOI: 10.17235/reed.2015.3768/2015

Citation tools
Sánchez-Aldehuelo R, García García de Paredes A, Rojo Lázaro D, Martínez Ortega A, García de la Filia Molina I, López-Durán S, et all. Outcomes of drug-induced acute pancreatitis: a ten-year experience of an academic center. 7443/2020


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 412 visits.
This article has been downloaded 323 times.

Statistics from Dimensions


Statistics from Plum Analytics

Publication history

Received: 27/07/2020

Accepted: 07/09/2020

Online First: 01/12/2020

Published: 07/04/2021

Article revision time: 40 days

Article Online First time: 127 days

Article editing time: 254 days


Share
This article hasn't been rated yet.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology