Year 2010 / Volume 102 / Number 11
Original
Irritable bowel syndrome immune hypothesis. Part one: the role of lymphocytes and mast cells

pp. 637-647

M. Ortiz Lucas, P. Saz Peiró y J. J. Sebastián Domingo

Abstract
Objective: To review the available evidence on the role of Tlymphocytes and mast cells in the etiopathogenesis of Irritable Bowel Syndrome.

Methods: Bibliographic retrieval on PubMed including the terms “Irritable Bowel Syndrome, “Immune System”, “T-Lymphocytes”
and “Mast Cells”.

Results: Twenty-five case-control studies and one randomized controlled trial were retrieved. Noteworthy in the blood is the increase
in activated T cells destined to migrate to the bowel in these patients. A high frequency of T-lymphocytes is described in the intestinal mucosa, although the study findings are, at times,
contradictory. An evident increase in mast cells (and in their activity) between the terminal ileum and descending colon is also observed.

Conclusions: The heterogeneity of diagnostic criteria and experimentation methods could account for some of the differences
in the results found in the selected research. There are indications that give reason to believe these patients have “low-grade intestinal
inflammation”, and the increase in T-lymphocytes and mast cells has been associated with disorders found in IBS such as the communication between the intestine and the nervous system, the
increase in intestinal permeability and changes in the microbiota.
Share Button
New comment
Comments
No comments for this article
Related articles
Citation tools
M. Ortiz Lucas, P. Saz Peiró y J. J. Sebastián Domingo. Irritable bowel syndrome immune hypothesis. Part one: the role of lymphocytes and mast cells. 637-647


Download to a citation manager

Download the citation for this article by clicking on one of the following citation managers:

Metrics
This article has received 291 visits.
This article has been downloaded 15 times.
Share
This article has been rated by 1 readers.
Reader rating:
Valora este artículo:




Asociación Española de Ecografía Digestiva Sociedad Española de Endoscopia Digestiva Sociedad Española de Patología Digestiva
The Spanish Journal of Gastroenterology is the official organ of the Sociedad Española de Patología Digestiva, the Sociedad Española de Endoscopia Digestiva and the Asociación Española de Ecografía Digestiva
Cookie policy Privacy Policy Legal Notice © Copyright 2023 y Creative Commons. The Spanish Journal of Gastroenterology