Year 2010 / Volume 102 / Number 6
Notas
Gastrointestinal stromal tumors (GISTs) of the colon

pp. 388-390

F. Macías García, P. Parada, L. Martínez-Lesquereux, E. Pintos, M. Fraga y J. E. Domínguez Muñoz

Abstract
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal (GI) tract. Although they may arise anywhere of GI tract, colonic presentation is infrequent. We report 2 new cases of colonic GISTs localized at descending and sigmoid colon. Endoscopic biopsies were diagnostic
for GISTs and no distant metastasis were observed. Both cases underwent resective surgery as the only treatment. No recurrence
was observed during the follow-up period. In this clinical note we review the diagnosis, management and therapeutical options in
colonic GISTs, according to literature. KIT immunoreactivity is the base for diagnosis. Risk of malignancy is based on the primary tumor
diameter and the mitotic count. Anatomic localization is not an independent prognostic factor. Surgery is the standard treatment
for localized primary disease and imatinib is indicated if metastatic or unresectable GISTs
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F. Macías García, P. Parada, L. Martínez-Lesquereux, E. Pintos, M. Fraga y J. E. Domínguez Muñoz. Gastrointestinal stromal tumors (GISTs) of the colon. 388-390


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