Year 2020 / Volume 112 / Number 8
Letter
Dasatinib-induced colitis: discovering the side effects of immunotherapy

663-664

DOI: 10.17235/reed.2020.6789/2019

Víctor Jiménez Beltrán, Auxiliadora Bermúdez Alarcón, Olegario Castaño Fernández,

Abstract
The effects of immunotherapy are numerous and are still being discovered. We present a case report of a patient who received dasatinib for chronic myeloid leukemia. A colonoscopy was performed due to a positive fecal occult blood test and colitis was observed. Furthermore, she also had a cytomegalovirus infection. This case highlights the importance to detect cases of immunomodulatory drugs induced colitis by the fecal occult blood test.
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References
Naqvi K, Jabbour E, Skinner J, et al. Long-term follow-up of lower dose dasatinib (50 mg daily) as frontline therapy in newly diagnosed chronic-phase chronic myeloid leukemia. Cancer, 2019, Sep 25.
Suh KJ, Lee JY, Shin DY, et al. Analysis of adverse events associated with dasatinib and nilotinib treatments in chronic-phase chronic myeloid leukemia patients outside clinical trials. Int J Hematol. 2017 Aug; 106 (2):229-239.
Nishiwaki S, Maeda M, Yamada M, et al. Clinical efficacy of fecal occult blood test and colonoscopy for dasatinib-induced hemorrhagic colitis in CML patients. Blood 2017 129:126-128.
Mesonero, F; López-Sanromán, A; Madariaga, A; et al. Colitis secundaria a ipilimumab: un nuevo reto para el gastroenterólogo. Gastroenterol Hepatol. 2016, Mar; 39 (3): 233-8.
Choi JK, Cho SY, Choi SM, et al. Cytomegalovirus Colitis during Dasatinib Treatment for Patients with Hematologic Malignancy: Case Series and Literature Review. Infect and Chemother. 2018 Jun; 50(2):153-159.
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Jiménez Beltrán V, Bermúdez Alarcón A, Castaño Fernández O. Dasatinib-induced colitis: discovering the side effects of immunotherapy. 6789/2019


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Publication history

Received: 04/12/2019

Accepted: 08/01/2020

Online First: 20/07/2020

Published: 30/07/2020

Article Online First time: 229 days

Article editing time: 239 days


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