Año 2022 / Volumen 114 / Número 2
Original
Auditory and visual P300 event-related potentials to detect minimal hepatic encephalopathy

83-88

DOI: 10.17235/reed.2021.7709/2020

Ángel Daniel Santana-Vargas, Fátima Higuera-De la Tijera, José Luis Pérez-Hernández,

Resumen
Introduction: the diagnosis of minimal hepatic encephalopathy (MHE) requires psychometric tests, although new methods are needed since their sensitivity, specificity, and accuracy are low. The P300 event-related potential (ERP) is obtained by auditory and visual stimuli, although only the auditory P300 has been used to detect MHE. This study aimed to compare the diagnostic features of auditory and visual P300 to detect MHE. Materials and methods: sixty patients with liver cirrhosis and thirty-five healthy controls completed the Psychometric Hepatic Encephalopathy Score (PHES), the critical flicker frequency (CFF), and auditory and visual P300 tests. MHE was diagnosed if PHES and CFF scores were abnormal. Results: fifty-three cirrhotic patients (aged 54.5 ± 8.6 years) completed all tests. Abnormal scores were obtained for PHES (49.1 %) and CFF (67.9 %). The proportion of MHE was 21.4 %. The area under the receiver operating (ROC) curves (AUROC) for auditory P300 was better than for visual P300 for distinguishing MHE from controls (AUROC: 0.792 vs 0.725; p < 0.005 for both; accuracy: 73.8 % vs 70.2 %; sensitivity: 72.2 % for both; specificity: 74.2 vs 69.7, respectively). Among cirrhotic patients, only auditory P300 was useful to detect MHE (AUROC: 0.723; p < 0.05; 77.4 % accuracy; 61.1 % sensitivity, and 81.8 % specificity). Conclusions: auditory P300 sensitivity, specificity, and accuracy were similar to those of CFF. Our results showed that only auditory P300 is useful to differentiate patients with MHE, although both modalities, auditory and visual, differentiated patients with cirrhosis from controls. Thus, we consider that visual P300 is not suitable for detecting MHE.
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Santana-Vargas Á, Higuera-De la Tijera F, Pérez-Hernández J. Auditory and visual P300 event-related potentials to detect minimal hepatic encephalopathy. 7709/2020


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Ficha Técnica

Recibido: 07/12/2020

Aceptado: 23/01/2021

Prepublicado: 10/02/2021

Publicado: 07/02/2022

Tiempo de revisión del artículo: 38 días

Tiempo de prepublicación: 65 días

Tiempo de edición del artículo: 427 días


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