Year 2021 / Volume 113 / Number 10
Letter
Symptomatic hypomagnesemia induced by proton-pump inhibitors (PPIs). A known adverse event that is worth recalling

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DOI: 10.17235/reed.2021.7882/2021

Alma Keco Huerga, Jesús García de la Borbolla Serres, Manuel Castro Fernández,

Abstract
In 2016, the Sociedad Española de Patología Digestiva published a paper on the adverse effects of PPIs, including a position statement on their safety, with the conclusion that they are uncommon and usually of little importance. Magnesium deficiency was assessed among PPI adverse events.
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References
1.- De la Coba C, Argüelles-Arias F, Martín de Argila C, et al. Efectos adversos de los inhibidores de la bomba de protones: revisión de evidencias y posicionamiento de la Sociedad Española de Patología Digestiva. Rev Esp Enferm Dig 2016; 108: 207-224.
2.- Agencia Española de Medicamentos y Productos Sanitarios (AEMPS). Riesgo de hipomagnesemia asociado a los medicamentos inhibidores de la bomba de protones (IBP). Ref. MUH (FV), 27/2011. Accesible en: http://www.aemps.gob.es/informa/notasInformativas /medicamentosUsoHumano/seguridad/2011/docs/NI-MUH_27-2011.pdf.
3.-Hess MW, Hoenderop JGJ, Bindels RJM, et al. Systematic review: hypomagnesaemia induced by proton pump inhibition. Aliment Pharmacol Ther 2012;36:405-413.
4.- Park CH, Kin EH, Roth YH, et al. The association between the use of proton pump inhibitors and the risk of hypomagnesemia. A systematic review and meta-analysis. . PLoS ONE 2014; 9 (11): e112558.
5.- Delgado MG, Calleja S, Suarez L, et al. J. Recurrent confusional episodes associated with hypomagnesaemia due to esomeprazol. BMJ Case Rep 2013. Doi: 10.1136/bcr-2013-200501.
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Keco Huerga A, García de la Borbolla Serres J, Castro Fernández M. Symptomatic hypomagnesemia induced by proton-pump inhibitors (PPIs). A known adverse event that is worth recalling. 7882/2021


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Publication history

Received: 10/02/2021

Accepted: 12/02/2021

Online First: 15/03/2021

Published: 06/10/2021

Article Online First time: 33 days

Article editing time: 238 days


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