Year 2023 / Volume 115 / Number 2
Letter
Iron pill-induced gastritis: an unrecognized side effect of iron-deficiency anemia

100

DOI: 10.17235/reed.2022.9005/2022

Catarina Correia, Elisa Gravito-Soares, Marta Gravito-Soares, Maria Augusta Cipriano, Pedro Amaro,

Abstract
Iron-deficiency anemia is a prevalent condition usually treated with iron supplementation. Iron pill–induced gastritis is an under-recognized, albeit serious potential complication of iron pill ingestion in the upper gastrointestinal tract. This entity must be identified by healthcare providers who prescribe iron. The diagnosis of this unusual drug-induced disease is based on endoscopic findings and histopathological examination, because the clinical symptoms are vague and non-specific. Herein we report a case of a 79-year-old woman with iron-deficiency anemia taking oral ferrous sulfate with multiple congestive and eroded polypoid lesions. Histology showed an H. pylori-negative erosive gastritis with iron deposition, confirming the diagnosis of iron pill–induced gastritis. The aim of this report is to highlight that iron pill-induced gastritis is an under-diagnosed entity that must be kept in mind when patients undergo chronic iron-pill therapy because it can lead to serious complications of the upper gastrointestinal tract.
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References
[1] McLean E, Cogswell M, Egli I, Wojdyla D, De Benoist B. Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993-2005. Public Health Nutr. 2009;12(4):444–54.
[2] Kaye P, Abdulla K, Wood J, James P, Foley S, Ragunath K, et al. Iron-induced mucosal pathology of the upper gastrointestinal tract: A common finding in patients on oral iron therapy. Histopathology. 2008;53(3):311–7.
[3] Marginean EC, Bennick M, Cyczk J, Robert ME, Jain D. Gastric siderosis: Patterns and significance. Am J Surg Pathol. 2006;30(4):514–20.
[4] Sunkara T, Caughey ME, Nigar S, Olivo R, Gaduputi V. Iron Pill Gastritis: An Under Diagnosed Condition With Potentially Serious Outcomes. Gastroenterol Res. 2017;10(2):138–40.
[5] Kothadia JP, Arju R, Kaminski M, Mahmud A, Chow J, Giashuddin S. Gastric siderosis: An under-recognized and rare clinical entity. SAGE Open Med. 2016;4:205031211663210.
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Correia C, Gravito-Soares E, Gravito-Soares M, Cipriano M, Amaro P. Iron pill-induced gastritis: an unrecognized side effect of iron-deficiency anemia. 9005/2022


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Publication history

Received: 14/06/2022

Accepted: 21/06/2022

Online First: 24/06/2022

Published: 07/02/2023

Article Online First time: 10 days

Article editing time: 238 days


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