Year 2022 / Volume 114 / Number 8
Original
Impact of the COVID-19 lockdown on liver transplant recipients. A single center observational study

448-454

DOI: 10.17235/reed.2021.8173/2021

Antonio Cuadrado, Luis M Gaite, Aitor Odriozola, Rosario Oloriz, Sara Herrera, José I Fortea, Lidia Amigo, Edward J. Anderson, Jesús A. Artal, Javier Crespo, Emilio Fábrega,

Abstract
Background: the impact of the COVID-19 outbreak and lockdown on liver transplant (LT) patients remains unknown. The aim of this cross-sectional study was to assess the consequences of the COVID-19 pandemic on the physical and mental health of LT patients during the lockdown period. Methods: a web-based questionnaire was emailed to 238 LT patients undergoing regular follow-up at our unit between August and October 2020. This pseudonymized survey explored demographic and lifestyle variables (i.e., eating and physical habits), disruptions in routine medical care, different dimensions of mental health, COVID-19-related mood and coping (worries/anxiety, depression, insomnia, fear of COVID, resilience, etc.) and health perception using different validated instruments. Results: altogether, 48.7 % (116 of 238) LT recipients accepted to participate in the study, 104 of whom gave their consent to publish the data. The median age was 63 years. Up to 39.4 % presented worrying scores indicating moderate/severe generalized anxiety disorder (GAD), whereas 25.5 % exhibited moderate/severe insomnia and only 10.5 % moderate/severe depression. Forty patients (38.5 %) gained weight, 24 % experienced a worsening in their eating habits and 63.4 % referred to practicing less or much less exercise during the lockdown. Only 25 % perceived a worsening in the control of their chronic comorbidities. Missed medical appointments (0.9 %) or poor adherence to therapy (1.9 %) were exceptional. Conclusions: COVID-19 lockdown has negatively impacted the mental and physical health of LT patients. Long-term consequences remain unclear.
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References
1. WHO. Coronavirus disease (COVID-19) pandemic Web site. https://www.who.int Published January 30, 2020. Accessed December 1, 2020.
2. Real Decreto 463/2020, de 14 de marzo, por el que se declara el estado de alarma para la gestión de la situación de crisis sanitaria ocasionada por el COVID-19. https://www.boe.es/boe/dias/2020/03/14/pdfs/BOE-A-2020-3692.pdf Published March 14, 2020. Accessed December 1, 2020.
3. Bao Y, Sun Y, Meng S, Shi J, et al.. 2019-nCoV epidemic: address mental health care to empower society. Lancet. 2020 Feb 22;395(10224):e37-e38. Epub 2020/02/12. doi:10.1016/S0140-6736(20)30309-3. Cited in: Pubmed; PMID 32043982.
4. Brooks SK, Webster RK, Smith LE, et al. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet. 2020 Mar 14;395(10227):912-920. Epub 2020/03/01. doi:10.1016/S0140-6736(20)30460-8. Cited in: Pubmed; PMID 32112714.
5. Jeong H, Yim HW, Song YJ, et al. Mental health status of people isolated due to Middle East Respiratory Syndrome. Epidemiol Health. 2016;38:e2016048. Epub 2017/02/16. doi:10.4178/epih.e2016048. Cited in: Pubmed; PMID 28196409.
6. Shigemura J, Ursano RJ, Morganstein JC, et al. Public responses to the novel 2019 coronavirus (2019-nCoV) in Japan: Mental health consequences and target populations. Psychiatry Clin Neurosci. 2020 Apr;74(4):281-282. Epub 2020/02/09. doi:10.1111/pcn.12988. Cited in: Pubmed; PMID 32034840.
7. Vindegaard N, Benros ME. COVID-19 pandemic and mental health consequences: Systematic review of the current evidence. Brain Behav Immun. 2020 Oct;89:531-542. Epub 2020/06/03. doi:10.1016/j.bbi.2020.05.048. Cited in: Pubmed; PMID 32485289.
8. Clay JM, Parker MO. Alcohol use and misuse during the COVID-19 pandemic: a potential public health crisis? Lancet Public Health. 2020 May;5(5):e259. Epub 2020/04/12. doi:10.1016/S2468-2667(20)30088-8. Cited in: Pubmed; PMID 32277874.
9. Ahorsu DK, Lin CY, Imani V, et al. The Fear of COVID-19 Scale: Development and Initial Validation. Int J Ment Health Addict. 2020 Mar 27:1-9. Epub 2020/04/01. doi:10.1007/s11469-020-00270-8. Cited in: Pubmed; PMID 32226353.
10. Meyer TJ, Miller ML, Metzger RL, et al. Development and validation of the Penn State Worry Questionnaire. Behav Res Ther. 1990;28(6):487-95. Epub 1990/01/01. doi:10.1016/0005-7967(90)90135-6. Cited in: Pubmed; PMID 2076086.
11. Sandin B CP, Valiente RM, Lostao L. Validación Española del Cuestionario de Preocupación PSWQ: Estructura factorial y propiedades psicométricas. Rev Psicopatol Psicol Clin. 2009;14:107-22.
12. Rodriguez-Rey R, Alonso-Tapia J, Hernansaiz-Garrido H. Reliability and validity of the Brief Resilience Scale (BRS) Spanish Version. Psychol Assess. 2016 May;28(5):e101-e110. Epub 2015/10/27. doi:10.1037/pas0000191. Cited in: Pubmed; PMID 26502199.
13. Smith BW, Dalen J, Wiggins K, et al. The brief resilience scale: assessing the ability to bounce back. Int J Behav Med. 2008;15(3):194-200. Epub 2008/08/13. doi:10.1080/10705500802222972. Cited in: Pubmed; PMID 18696313.
14. Fernandez-Mendoza J, Rodriguez-Munoz A, Vela-Bueno A, et al. The Spanish version of the Insomnia Severity Index: a confirmatory factor analysis. Sleep Med. 2012 Feb;13(2):207-10. Epub 2011/12/17. doi:10.1016/j.sleep.2011.06.019. Cited in: Pubmed; PMID 22172961.
15. Brugha T, Bebbington P, Tennant C, et al. The List of Threatening Experiences: a subset of 12 life event categories with considerable long-term contextual threat. Psychol Med. 1985 Feb;15(1):189-94. Epub 1985/02/01. doi:10.1017/s003329170002105x. Cited in: Pubmed; PMID 3991833.
16. Motrico E, Moreno-Kustner B, de Dios Luna J, et al. Psychometric properties of the List of Threatening Experiences--LTE and its association with psychosocial factors and mental disorders according to different scoring methods. J Affect Disord. 2013 Sep 25;150(3):931-40. Epub 2013/06/04. doi:10.1016/j.jad.2013.05.017. Cited in: Pubmed; PMID 23726778.
17. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606-13. Epub 2001/09/15. doi:10.1046/j.1525-1497.2001.016009606.x. Cited in: Pubmed; PMID 11556941.
18. Brooks R. EuroQol: the current state of play. Health Policy. 1996 Jul;37(1):53-72. Epub 1996/06/06. doi:10.1016/0168-8510(96)00822-6. Cited in: Pubmed; PMID 10158943.
19. Reuken PA, Rauchfuss F, Albers S, et al. Between fear and courage: Attitudes, beliefs, and behavior of liver transplantation recipients and waiting list candidates during the COVID-19 pandemic. Am J Transplant. 2020 Nov;20(11):3042-3050. Epub 2020/06/10. doi:10.1111/ajt.16118. Cited in: Pubmed; PMID 32515125.
20. Conway TL, Vickers RR, Jr., Ward HW, et al. Occupational stress and variation in cigarette, coffee, and alcohol consumption. J Health Soc Behav. 1981 Jun;22(2):155-65. Epub 1981/06/01. Cited in: Pubmed; PMID 7240714.
21. Hong Z, Li N, Li D, et al. Telemedicine During the COVID-19 Pandemic: Experiences From Western China. J Med Internet Res. 2020 May 8;22(5):e19577. Epub 2020/05/01. doi:10.2196/19577. Cited in: Pubmed; PMID 32349962.
22. Mills EC, Savage E, Lieder J, et al. Telemedicine and the COVID-19 Pandemic: Are We Ready to Go Live? Adv Skin Wound Care. 2020 Aug;33(8):410-417. Epub 2020/07/24. doi:10.1097/01.ASW.0000669916.01793.93. Cited in: Pubmed; PMID 32701252.
23. Patel S, Douglas-Moore J. A reflection on an adapted approach from face-to-face to telephone consultations in our Urology Outpatient Department during the COVID-19 pandemic - a pathway for change to future practice? BJU Int. 2020 Sep;126(3):339-341. Epub 2020/05/30. doi:10.1111/bju.15119. Cited in: Pubmed; PMID 32469096.
24. Cellini N, Canale N, Mioni G, et al. Changes in sleep pattern, sense of time and digital media use during COVID-19 lockdown in Italy. J Sleep Res. 2020 Aug;29(4):e13074. Epub 2020/05/16. doi:10.1111/jsr.13074. Cited in: Pubmed; PMID 32410272.
25. Pierce M, Hope H, Ford T, et al. Mental health before and during the COVID-19 pandemic: a longitudinal probability sample survey of the UK population. Lancet Psychiatry. 2020 Oct;7(10):883-892. Epub 2020/07/25. doi:10.1016/S2215-0366(20)30308-4. Cited in: Pubmed; PMID 32707037.
26. Rossi R, Socci V, Talevi D, et al. COVID-19 Pandemic and Lockdown Measures Impact on Mental Health Among the General Population in Italy. Front Psychiatry. 2020;11:790. Epub 2020/08/28. doi:10.3389/fpsyt.2020.00790. Cited in: Pubmed; PMID 32848952.
27. Salari N, Hosseinian-Far A, Jalali R, et al. Prevalence of stress, anxiety, depression among the general population during the COVID-19 pandemic: a systematic review and meta-analysis. Global Health. 2020 Jul 6;16(1):57. Epub 2020/07/08. doi:10.1186/s12992-020-00589-w. Cited in: Pubmed; PMID 32631403.
28. Xiao H, Zhang Y, Kong D, et al. The Effects of Social Support on Sleep Quality of Medical Staff Treating Patients with Coronavirus Disease 2019 (COVID-19) in January and February 2020 in China. Med Sci Monit. 2020 Mar 5;26:e923549. Epub 2020/03/07. doi:10.12659/MSM.923549. Cited in: Pubmed; PMID 32132521.
29. Xiao H, Zhang Y, Kong D, et al. Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Disease 2019 (COVID-19) Outbreak in January 2020 in China. Med Sci Monit. 2020 Mar 20;26:e923921. Epub 2020/03/21. doi:10.12659/MSM.923921. Cited in: Pubmed; PMID 32194290.
30. Altena E, Baglioni C, Espie CA, et al. Dealing with sleep problems during home confinement due to the COVID-19 outbreak: Practical recommendations from a task force of the European CBT-I Academy. J Sleep Res. 2020 Aug;29(4):e13052. Epub 2020/04/05. doi:10.1111/jsr.13052. Cited in: Pubmed; PMID 32246787.
31. Voitsidis P, Gliatas I, Bairachtari V, et al. Insomnia during the COVID-19 pandemic in a Greek population. Psychiatry Res. 2020 May 12;289:113076. Epub 2020/11/27. doi:10.1016/j.psychres.2020.113076. Cited in: Pubmed; PMID 33242799.
32. Schoeller DA. The effect of holiday weight gain on body weight. Physiol Behav. 2014 Jul;134:66-9. Epub 2014/03/26. doi:10.1016/j.physbeh.2014.03.018. Cited in: Pubmed; PMID 24662697.
33. Lee IM, Shiroma EJ, Lobelo F, et al. Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet. 2012 Jul 21;380(9838):219-29. Epub 2012/07/24. doi:10.1016/S0140-6736(12)61031-9. Cited in: Pubmed; PMID 22818936.
34. Poelman MP, Gillebaart M, Schlinkert C, et al. Eating behavior and food purchases during the COVID-19 lockdown: A cross-sectional study among adults in the Netherlands. Appetite. 2021 Feb 1;157:105002. Epub 2020/10/18. doi:10.1016/j.appet.2020.105002. Cited in: Pubmed; PMID 33068668.
35. Saqib MAN, Siddiqui S, Qasim M, et al. Effect of COVID-19 lockdown on patients with chronic diseases. Diabetes Metab Syndr. 2020 Nov-Dec;14(6):1621-1623. Epub 2020/09/06. doi:10.1016/j.dsx.2020.08.028. Cited in: Pubmed; PMID 32889403.
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Cuadrado A, Gaite L, Odriozola A, Oloriz R, Herrera S, Fortea J, et all. Impact of the COVID-19 lockdown on liver transplant recipients. A single center observational study . 8173/2021


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Publication history

Received: 22/06/2021

Accepted: 01/08/2021

Online First: 02/09/2021

Published: 27/07/2022

Article Online First time: 72 days

Article editing time: 400 days


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