Year 2002 / Volume 94 / Number 2
Original
Lung changes and cytokine levels in a model of experimental acute pancreatitis

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G. Mozo, Mª. L. del Olmo, A. Caro-Patón, E. Reyes, L. Manzano, A. Belmonte y M. Álvarez-Mon

Abstract
Aim: prognosis of acute pancreatitis is related mainly to systemic involvement. The establishment of this systemic inflammation is mediated by proinflammatory cytokines. Our aim is to study serum levels of some proinflammatory cytokines and the associated damage of the lung in a model of experimental acute pancreatitis.
Experimental design: eighty seven male Wistar rats were divided into two groups: group A (control) with saline solution administration; group B with acute pancreatitis induced by intraperitoneal
caerulein (50 mg/kg every hour, 4 doses). The animals were killed at 0, 2, 6 and 24 hours of the last dose of caerulein or saline solution. Pancreatic and pulmonary histology were examined, and
serum levels of IL-1ß, TNF-& and IL-6 were evaluated, as well as some laboratory parameters as indicators of systemic involvement.

Results: the administration of caerulein induced an acute edematous pancreatitis without mortality and with a trend towards resolution in 24 hours. IL-1ß in animals with acute pancreatitis showed
significantly higher levels than in the control group at 6 hours. Serum transaminases, urea and creatinine were also significantly higher at 2 and 6 h. The group with acute pancreatitis showed
histological lung damage all over the study.

Conclusions: in our model of acute pancreatitis we observed systemic involvement as judged by alterations of serum transaminases and parameters of renal function, as well as histological lung
damage, that correlated with an increase in serum levels of IL-1b.
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G. Mozo, Mª. L. del Olmo, A. Caro-Patón, E. Reyes, L. Manzano, A. Belmonte y M. Álvarez-Mon. Lung changes and cytokine levels in a model of experimental acute pancreatitis. 0


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