Year 2025 / Volume 117 / Number 11
Letter
Lamotrigine induced drug reaction with eosinophilia and systemic symptoms (DRESS) presenting with eosinophilic pan-colitis, cholestasis and cytomegalovirus reactivation

683-684

DOI: 10.17235/reed.2024.10681/2024

Joel Omar Jáquez-Quintana, César Ramos-Matamoros, Carlos Eugenio Gonzalez-Martinez, José Luis Herrera Elizondo,

Abstract
The drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is an idiosyncratic drug-induced reaction that primarily affects the liver, lungs, and kidneys. While several organs are commonly involved, the incidence of DRESS affecting the gastrointestinal tract is rarely reported. We present a 72-year-old man with a history of epilepsy who developed DRESS syndrome manifested by eosinophilic pancolitis, cholestasis, and reactivation of cytomegalovirus (CMV) following the initiation of lamotrigine.
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References
1. Calle AM, Aguirre N, Ardila JC, Cardona Villa R. DRESS syndrome: A literature review and treatment algorithm. World Allergy Organ J. 2023;16(3):100673. DOI: 10.1016/j.waojou.2022.100673
2. Parsi M, Daniel C. Lamotrigine-induced DRESS Syndrome Manifesting as 'Eosinophilic Colitis': An Uncommon Presentation of a Very Uncommon Condition. Cureus. 2020;12(4):e7570. DOI:10.7759/cureus.7570
3. Jevtic D, Dumic I, Nordin T, et al. Less Known Gastrointestinal Manifestations of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome: A Systematic Review of the Literature. J Clin Med. 2021;10(18):4287. DOI:10.3390/jcm10184287
4. Mizukawa Y, Hirahara K, Kano Y, Shiohara T. Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms severity score: A useful tool for assessing disease severity and predicting fatal cytomegalovirus disease. J Am Acad Dermatol. 2019;80(3):670-678.e2. DOI:10.1016/j.jaad.2018.08.052
5. Cabañas R, Ramírez E, Sendagorta E, et al. Spanish Guidelines for Diagnosis, Management, Treatment, and Prevention of DRESS Syndrome. J Investig Allergol Clin Immunol. 2020;30(4):229-253. DOI:10.18176/jiaci.0480
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Citation tools
Jáquez-Quintana J, Ramos-Matamoros C, Gonzalez-Martinez C, Herrera Elizondo J. Lamotrigine induced drug reaction with eosinophilia and systemic symptoms (DRESS) presenting with eosinophilic pan-colitis, cholestasis and cytomegalovirus reactivation. 10681/2024


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Publication history

Received: 25/07/2024

Accepted: 29/07/2024

Online First: 05/09/2024

Published: 11/11/2025

Article Online First time: 42 days

Article editing time: 474 days


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